Physical sign

As indicated above, Man 6-P serves as a chemical marker to target certain lysosomal enzymes to that organelle. Analysis of cultured fibroblasts derived from patients with I-cell (inclusion cell) disease played a large part in revealing the above role of Man 6-P. I-cell disease is an uncommon condition characterized by severe progressive psychomotor retardation and a variety of physical signs, with death often occurring in the first decade. Cultured cells from patients with I-cell disease were found to lack almost all of the normal lysosomal enzymes the lysosomes thus accumulate many different... 

What are the possible physical signs and symptoms of cocaine use ... 

Brudzinsld s sign A physical sign associated with meningitis, in which flexion of the hips and knees occurs when the neck is flexed... 

Chvostek s sign The physical sign noted when a tap on the patient s facial nerve adjacent to the ear produces a brief contraction of the upper lip, nose, or side of the face. 

Hepatojugular reflex A physical sign evidenced by distention of the jugular vein with application of pressure on the abdomen over the liver. 

Physical signs may include hypotension tachycardia, bradycardia, irregular or no pulse cyanosis hypothermia and distant or absent heart and lung sounds. 

Symptoms of DVT include unilateral leg swelling, pain, tenderness, erythema, and warmth. Physical signs may include a palpable cord and a positive Homans sign. 

Physical signs include coarse skin and hair, cold or dry skin, periorbital puffiness, bradycardia, and slowed or hoarse speech. Objective weakness (with proximal muscles being affected more than distal muscles) and slow relaxation of deep tendon reflexes are common. Reversible neurologic syndromes such as carpal tunnel syndrome, polyneuropathy, and cerebellar dysfunction may also occur. 

Most children born with HIV are asymptomatic. On physical examination, they often present with unexplained physical signs such as lymphadenop-athy, hepatomegaly, splenomegaly, failure to thrive, and weight loss or unexplained low birth weight, and fever of unknown origin. Laboratory... 

Physical signs and symptoms of LSD intoxication include mydriasis, tachycardia, diaphoresis, palpitations, blurred vision, tremor, incoordination, dizziness, weakness, and drowsiness psychiatric signs and symptoms include perceptual intensification, depersonalization, derealization, illusions, psychosis, and synesthesia. There is no withdrawal syndrome after discontinuation. 

Physiologic effects are relatively few. Dilated pupils, hyperreflexia, increased muscle tension, incoordination, and ataxia are common physical signs. Effects on pulse rate, respiration, and blood pressure are so variable that they probably represent varying levels of anxiety of subjects rather than true physiologic effects. Changes in appetite and salivation are inconstant, being increased in some subjects and decreased in others. 

Cases of -hexane toxicity in humans have occurred as the result of workplace exposure and solvent abuse (Spencer et al. 1980). Some of these cases of peripheral neuropathy have occurred in teenagers (particularly with solvent abuse) however, none of the clinical reports indicate differences in physical signs or functional tests between this group and adults (Altenkirch et al. 1977 Yamamura et al. 1969). While no reports of -hexane toxicity in young children were located, it is probable that similar toxicity would occur if exposure was comparable to that in affected adults. Specific information is not available on whether children are more susceptible than adults to the effects of -hexane. 

Physical Examination Systematic and thorough inspection of the patient for physical signs... 

Humans are the only species that do not show any visually observable physical sign of ovulation, and human female sexual cripsis is thought to be complete. In this preliminary approach we tried to find out if female body movements change qualitatively during cycle. In order to accomplish this 150 video clips (duration four seconds each) of a female... 

Surrogate endpoints, a subset of biomarkers, are laboratory measurements or physical signs used in therapeutic trials as a substitute for clinical endpoints expected to predict the effect of the therapy. A fully validated, surrogate endpoint predicts the clinically meaningful endpoint of a therapy consistently. ... 

TABLE 7.3. Some Physical Signs of Anorexia Nervosa... 

Although those with bulimia usually maintain a relatively normal body weight, there are nonetheless telltale physical signs of their aberrant eating behavior (see Table 7.7). Specific to BN are dental erosion, chubby cheeks from enlargement of the parotid salivary glands, and abrasions on the back of one hand from repetitive self-induced vomiting. 

If both maternal toxicity and effects on the conceptus have been found, the data should be examined on an individual animal basis to determine whether the females showing the most marked toxicity produced the offspring with the effects. In the author s experience, it is generally the case that there is no correlation on an individual animal basis between the maternal toxicity and the effects on the conceptus it is, therefore, not logical to posit a relationship between maternal toxicity and the effects on the conceptus. In these cases, any submission should contain a statement that the data have been analyzed to look for such a correlation and should produce confirmatory data. The confirmatory data should clearly demonstrate a relationship between the worst effects on the adults and the effects on reproduction. A simple list of unquantified physical signs affecting the whole group, for example, would not prove a connection. 

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