Phospholipid polymers phosphorylcholine

Phospholipid polymers having a 2-methacryloylox-yethyl phosphorylcholine (MPC) were investigated as a solubilizer for paclitaxel. The paclitaxel solubility was observed to increase up to 5.0mg/ml in the presence of a copolymer of MPC and Ai-butyl methacrylate (BMA), poly(MPC-co-BMA), with 70mol% of the BMA unit. The MPC polymer forms a polymer aggregate with the diameter of 23 nm, called a polymeric lipid nanosphere, in aqueous media by hydrophobic interaction, which may solubilize hydrophobic drugs. 

A biodegradable poly (ester urethane)urea (PEUU) was blended with a phospholipid polymer of poly(methacryloyloxyethyl phosphorylcholine-co-methacryloyloxyethyl butyl urethane) (PMBU) (molar ratio=70/30), in HFIP solvent, and then coelectfospun... 

The response of blomolecules and cell membranes Is determined by many factors, some of which are the chemical composition and conformation of the molecules, the surface energy, and topography of the top surface layers which are in contact with biological systems, I.e., body fluids and cells [45]. The work illustrated here consisted In designing new polymers with functional properties capable of promoting the attachment of specific cells. The first step consisted in a polymer system which surface inhibits non-specific cell attachment. This strategy is based on the incorporation of cell membrane constituents such as phosphorylcholine (PC) or phospholipid analogues into polymers [46-51]. 

The use of phospholipids to mimic cell walls has been one commercially successful coating strategy. To create a polymer surface with phospholipid-type properties, two routes are possible. The polymer surface can be modified by the attachment of the biological molecule of interest, as described in the modification of polymer surfaces with phosphorylcholine (72-74), amphiphilic molecules (75) or liposomes. Alternatively, phosphorylcholine moieties have been incorporated into artificial surfaces by using polymerizable precursors the most representative monomer is 2-methacryloxyethylphosphorylcholine (MFC) 16, 17). Block copolymers of phosphorylcholine with other hydrophobic comonomers like lauryl methacrylate (75) also have been found to be effective. 

New concepts for making blood compatible polymer materials have been proposed based on the characteristics of natural phospholipid molecules in plasma. It was considered that if a polymer surface possesses a phospholipid-like structure, a large amount of natural phospholipids in plasma can be adsorbed on the surface by their self-assembling character. Based on this idea, a methacrylate monomer with a phospholipid polar group, 2-methacryloyloxy ethyl phosphorylcholine (MFC), was designed and synthesized The polymers, composed of MFC and various alkyl methacrylates (as shown in Fig. 1) or styrene derivatives were prepared and their blood compatibility carefully evaluated ". Flatelet adhesion and activation were significantly suppressed on the surface of the MFC polymers when the MFC composition was above 30 mol%. These excellent... 

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