Polymer phospholipid

Ishihara K, Hanyuda H, and Nakabayashi N. Synthesis of phospholipids polymers having a urethane bond in the side chain as coating material on segmented polyurethane and their platelet adhesion resistant properties. Biomaterials, 1995, 16(11), 873-879. [Pg.252]

Ishihara, K., Ueda, T. and Nakabayashi, N. (1990) Preparation of phospholipid polymers and their properties as polymer hydrogel membranes. Polymer Journal, 22, 355-360. [Pg.207]

Ishihara, K. (2000) Bioinspired phospholipid polymer biomaterials for making high performance artificial organs. Science and Technology of Advanced Materials, 1, 131—138. [Pg.208]

Sakai-Kato, K., Kato, M., Ishihara, K. and Toyo-oka, T. (2004) An enzyme immobilization method for integration of biofunctions on a microchip using a water-soluble amphiphilic phospholipid polymer having a reacting group. Lab on a Chip, 4, 4—6. [Pg.208]

Cytocompatible Hydrogel Composed of Phospholipid Polymers for Regulation of Cell Functions... [Pg.141]

Keywords Cell encapsulation Cell engineering Cytocompatibility Hydrogel Phospholipid polymers... [Pg.142]

Cytocompatible Polymer Hydrogels Composed of Water-Soluble Phospholipid Polymers... [Pg.147]

Similarly to the phospholipid polymers, the MPC polymers show excellent biocompatibility and blood compatibility [43—48]. These properties are based on the bioinert character of the MPC polymers, i.e., inhibition of specific interaction with biomolecules [49, 50]. Recently, the MPC polymers have been applied to various medical and pharmaceutical applications [44-47, 51-55]. The crosslinked MPC polymers provide good hydrogels and they have been used in the manufacture of soft contact lenses. We have applied the MPC polymer hydrogel as a cell-encapsulation matrix due to its excellent cytocompatibility. At the same time, to prepare a spontaneously forming reversible hydrogel, we focused on the reversible covalent bonding formed between phenylboronic acid and polyol in an aqueous system. [Pg.147]

Watanabe J, Eriguchi T, Ishihara K (2002) Stereocomplex formation by enantiomeric poly (lactic acid) graft-type phospholipid polymers for tissue engineering. Biomacromolecules 3 1109-1114... [Pg.163]

Watanabe J, Ishihara K (2005) Cell engineering biointerface focusing on cytocompatibility using phospholipid polymer with an isomeric oligo(lactic acid) segment. Biomacromolecules 6 1797-1802... [Pg.163]

Kimura M, Fukumoto K, Watanabe J et al (2005) Spontaneously forming hydrogel from water-soluble random- and block-type phospholipid polymers. Biomaterials 26 6853-6862... [Pg.164]

Nam KW, Watanabe J, Ishihara K (2002) Characterization of the spontaneously forming hydrogels composed of water-soluble phospholipid polymers. Biomacromolecules 3 100-105... [Pg.164]

Ishiyama N, Moro T, Ishihara K et al (2010) The prevention of peritendinous adhesions by a phospholipid polymer hydrogel formed in situ by spontaneous intermolecular interactions. Biomaterials 31 4009 -016... [Pg.164]

Konno T, Ishihara K (2007) Temporal and spatially controllable cell encapsulation using a water-soluble phospholipid polymer with phenylboronic acid moiety. Biomaterials 28 1770-1777... [Pg.164]

Choi J, Konno T, Matsuno R et al (2008) Surface immobilization of biocompatible phospholipid polymer multilayered hydrogel on titanium alloy. Colloids Surf B Biointerfaces 67 216-223... [Pg.164]

Ishihara K, Takai M (2009) Bioinspired interfaces for nanobiodevices based on phospholipid polymer chemistry. J R Soc Interface 6 S279-S291... [Pg.164]

Ishihara K, Nomura H, Mihara T et al (1998) Why do phospholipid polymers reduce protein adsorption J Biomed Mater Res 39 323-330... [Pg.164]

Goda T, Ishihara K (2006) Soft contact lens biomaterials from bioinspired phospholipid polymers. Expert Rev Med Devices 3 167-174... [Pg.166]

Enzymatic conversion of NBD-labeled ArgOEt to NBD-Arg was monitored in a PMMA microchannel. The enzyme, trypsin, was immobilized via the reactive ester groups on a phospholipid polymer adsorbed on the PMMA surface [ 1059]. [Pg.362]

Oki, A., Adachi, S., Takamura, Y., Ishihara, K., Kataoka, K., Ichiki, T., Honike, Y., Glucose measurement in blood serum injected by electroosmosis into phospholipid polymer coated microcapillary. Micro Total Analysis Systems, Proceedings of the 4th IJ.TAS Symposium, Enschede, Netherlands, May 14-18, 2000, 403-406. [Pg.466]

Phospholipid polymers having a 2-methacryloylox-yethyl phosphorylcholine (MPC) were investigated as a solubilizer for paclitaxel. The paclitaxel solubility was observed to increase up to 5.0mg/ml in the presence of a copolymer of MPC and Ai-butyl methacrylate (BMA), poly(MPC-co-BMA), with 70mol% of the BMA unit. The MPC polymer forms a polymer aggregate with the diameter of 23 nm, called a polymeric lipid nanosphere, in aqueous media by hydrophobic interaction, which may solubilize hydrophobic drugs. [Pg.2922]

Other materials have also been studied for their ability to reduce protein adsorption onto surfaces. Because many cell membranes are based on phospholipids, polymers containing phospholipid-type head groups have been utilized for this purpose. Poly(2-methacroylethyl phosphoryl choline) could be plasma deposited onto silicone rubber and the adhesion of albumin reduced by factors of up to 80 (Fig. [Pg.1353]

FIGURE 4.6 Effects of polymer type on the cumulative release of triptorelin from lipospheres. Lipospheres were prepared from L-PLA (solid squares), PLGA 50 50 (open circles), or PLGA 75 25 (filled triangles) with HSPC in a 1 6 phospholipid/polymer ratio. Triptorelin (4 mg) was dissolved in N-methylpyrrolidone (500) p,L and mixed with a chloroformic solution of L-PLA and HSPC (1 mL). The release experiment was performed in pH 7.4 phosphate buffer, at 37°C, and analyzed by HPLC. (Adapted from [35] with permission from Wiley Sons.)... [Pg.15]

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