2-methacryloyloxy ethyl phosphorylcholine,

Poly(2-(methacryloyloxy)ethyl phosphorylcholine Poly(A -isopropylacrylamide)... 

Du and coworkers [122] prepared vesicles from poly(2-(methacryloyloxy)ethyl phosphorylcholine-fe-2-(diisopropylamino)ethyl methacrylate (PMPC-fe-PDPA) directly in water without any cosolvents. These vesicles are stable at physiological pH and completely dissociate below pH 6. Moreover, they are very close analogues of conventional liposomes due to the biomimetic phosphorylcholine motif. Further research demonstrated that these polymersomes are efficient systems for pH-controlled encapsulation and delivery of DNA [218],... 

Recently, the group of Battaglia used poly(2-(methacryloyloxy)ethyl-phosphorylcholine)-copoly(2-(diisopropylamino)ethyl methacrylate) (PMPC-PDPA) diblock copolymers to prepare biomimetic and pH-sensitive polymersomes for gene delivery [218]. These formulations encapsulated and released DNA in a pH-controlled manner. Notably, the pH drop was sufficient to trigger the transition from DNA-loaded vesicles to DNA-copolymer complexes. 

PMPC Poly[2-(methacryloyloxy) ethyl phosphorylcholine] E-field, T-field... 

Self-assembled block copolymers are basically amphilic molecules which contain distinctively different polymers. This block copolymer contains two or more polymers quantitatively in the form of blocks. Some of the block copolymers are polyacrylic acid, polymethylacrylate, polystyrene polyethylene oxide, polybutadiene, polybutylene oxide, poly-2-methyloxazoline, polydimethyl sUoxane, poly-e-caprolactone, polypropylene sulfide, poly-A -isopropylacrylamide, poly-2-vinylpyridine, poly-2-diethylamino ethyl methacrylate, poly-2-(diisopropylamino) ethyl methacrylate, poly-2-(methacryloyloxy) ethyl phosphorylcholine, and polylactic acid. These copolymers contain more than polymers to form certain configurations like linear, branched, patterned. For example, if we take three polymers named A, B, and C, they can be combined to form arrangements AB, BA, AA, BAB, ABCAB, ABCABC, ABABAB, etc. in the form of branched configuration it forms (ABQa, (ABA)a, (AB)4, etc. Depending on the above-mentioned number of blocks, they are named as AB diblock copolymers, ABC triblock copolymers, ABC star block copolymers, etc. The covalent linkage between these different blocks of polymers makes macroscopic phase separation impossible, that is, in its place the phase separation... 

Phosphobetaine monomers may also be prepared via a number of routes (239,274). Probably the most common phosphobetaine monomer is 2-(methacryloyloxy)ethyl phosphorylcholine (MPC), although other derivatives are also known (275-278). MPC is prepared from the reaction of 2-hydroxyethyl methacrylate with 2-chloro-2-oxo-l,3,2-dioxaphospholane, followed by ring... 

Block copolymers (poly-12- 7/ocfe-poly-74) were synthesized by ATRP of 2-(methacryloyloxy)ethyl-phosphorylcholine (74) by using poly-12 (R = PP) as a macroinitiator. 

Kobayashi M, Terayama Y, Hosaka N, Kaido M, Suzuki A, Yamada N, Torikai N, Ishihara K, Takahara A (2007) Frictirai behavior of high-density poly(2-methacryloyloxy-ethyl phosphorylcholine) brush in aqueous media. Soft Matter 3(6) 740... 

New concepts for making blood compatible polymer materials have been proposed based on the characteristics of natural phospholipid molecules in plasma. It was considered that if a polymer surface possesses a phospholipid-like structure, a large amount of natural phospholipids in plasma can be adsorbed on the surface by their self-assembling character. Based on this idea, a methacrylate monomer with a phospholipid polar group, 2-methacryloyloxy ethyl phosphorylcholine (MFC), was designed and synthesized The polymers, composed of MFC and various alkyl methacrylates (as shown in Fig. 1) or styrene derivatives were prepared and their blood compatibility carefully evaluated ". Flatelet adhesion and activation were significantly suppressed on the surface of the MFC polymers when the MFC composition was above 30 mol%. These excellent... 

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