Phospholipid analogues

1- phosphate 37 the ester carbonyl of the butyrate was part of this network, indicating that this moiety is in the so-called hydrogen belt area. For the 

Organogel formation by cholesterol derivatives has also been studied. Of a series of cholesterol derivatives with polyaromatic substituents, the anthracene derivative 43 was found to gelate solvents as diverse as dodecane and 1-octanol. Upon inspection by scanning electron microscopy (SEM), the 1-octanol gel was found to contain ribbon-like rectangular fibers (26.3 8.2 nm), the majority of which had a 

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Haase, R. et al., The phospholipid analogue hexadecylphosphatidylcholine inhibits phosphatidyl biosynthesis in Madin-Darby Canine Kidney Cells, FEBS Lett. 288, 129-132 (1991). 

A few cyclic phospholipid analogues 35a-c (n=13,15,17) were prepared in 78, 38, and 85% yields respectively, by reacting the corresponding 1-glyceryl ethers... 

Example 66 the phosphoroamidite route has been used to prepare phospholipid analogues holding biocompatible properties. Brown et al. [106] have prepared the 2-(methacryloyloxy)ethylphosphorylcholine monomer using the 2-iV,iSr-diisopropyl-l,3,2-dioxaphospholane which was coupled with 2-hydroxyethyl methacrylate (step a) in the presence of 4,5-dichloroimida-zole. 

Modulation of Protein Kinase C in Antitumor Treatment 2.3.2 Phospholipid Analogues... 

Geilen CC, Haase R, Buchner K, Wieder T, Hucho F, Reutter W (1991) The phospholipid analogue, hexadecylphosphocholine, inhibits protein kinase C in vitro and antagonises phorbol ester-stimtilated cell proliferation. Eur J Cancer 27 1650-1653... 

Phospholipid analogues, (I), of the current invention have been prepared (3) and are discussed. 

A series of phospholipid analogues (53)-(56) have been prepared and evaluated for their water solubility and inhibition of PLCbc- Their water solubility was enhanced by shortening the acyl side chains, reducing the number of acyl side chains, and by the introduction of a hydroxyl group on the termini of the acyl side chains. The key structural feature that conferred inhibitory activity on... 

Yuan, W., and Gelb, M. H. (1988). Phosphonate-containing phospholipid analogues as tight-binding inhibitors of phospholipase Aj.y. Am. Chem. Soc. 110, 2665-2666. Yuan, W., Quinn, D. M., Sigler, P. B., and Gelb, M. H. (1990). Kinetic and inhibition studies of phospholipase A2 with short-chain substrates and inhibitors. Biochemistry 29,6082-6094. 

Figure 1. Top Structures and CPK models of regioisomeric phospholipid analogues. Bottom (a, b) TEM micrographs of aggregates of 2. (a) Right-handed helices, (b) Superhelices formed by further assembly of the helices shown in (a). Inset freeze-fractured replica of the superhelix, (c) Schematic representation of the superhelical winding.

H-Phosphonate diesters of type 3 can be used in the preparation of phospholipid analogues 7 and 8 having a modified phosphorus center. 

Nederberg F, Bowden T, Hilbom J. Synthesis, characterization, and properties of phosphoryl choline functionalized poly e-caprolactone and charged phospholipid analogues. Macromolecules 2004 37 954-65. 

The response of blomolecules and cell membranes Is determined by many factors, some of which are the chemical composition and conformation of the molecules, the surface energy, and topography of the top surface layers which are in contact with biological systems, I.e., body fluids and cells [45]. The work illustrated here consisted In designing new polymers with functional properties capable of promoting the attachment of specific cells. The first step consisted in a polymer system which surface inhibits non-specific cell attachment. This strategy is based on the incorporation of cell membrane constituents such as phosphorylcholine (PC) or phospholipid analogues into polymers [46-51]. 

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