Phosphinates amino

Phosphine, amino-rhodium complexes catalysts, hydroformylation, 6,261 Phosphine, 3-aminopropyldimethyl-photographic fixer, 6,100 Phosphine, bis(2-carboxyethyl)methyl-photography... 

Synthesis of Hydrogen Phosphinate Amino Acid Analogues... 

Others CPSs have been prepared in a similar way and characterized at different steps by physicochemical methods. For example, the structure of the chiral selector iV-[2 -(5)-hydroxypropyl]-Ar, /V -bis(3,5- dichlorobenzoyl)-(f ,f )-tra i- 1,2-diamino-cyclohexane was solved by X-ray analysis and its absolute configuration confirmed unambiguously [73]. These CPS phases were used to resolve a large number of racemic mixtures belonging to different classes of organic compounds, such as a-aryloxyacetic acids, alcohols, sulfoxides, selenoxides, phosphinates, amino acids, amino alcohols, etc. 

Two phosphine amino acids were subsequently incorporated at i and + 4 positions in dodecapeptides by SPPS [93]. The peptide sequence was chosen so that the peptide should form an a-helical conformation, placing the two phosphorus atoms above each other on the same side of the helix, that is, in a potentially useful spatial orientation for metal chelating (Figure 10.19). 

These are water-soluble crystalline compounds sold as concentrated aqueous solutions. The methylol groups are highly reactive (118—122) and capable of being cured on the fabric by reaction with ammonia or amino compounds to form durable cross-linked finishes, probably having phosphine oxide stmctures after post-oxidizing. This finishing process, as developed by Albright Wilson, is known as the Proban process. 

Synthesis of azindines Irom epoxides via amino alcohols or azido alcohols and reaction with phosphines or phosphites... 

Phosphine" [dye Cl 793, Chrysaniline mononitrate, 3-amino-9-(4-aminophenyl)-acridinium mononitrate) [10181-37-0] M 348.4, m >250°(dec), pKesi 8.0. Crystd from benzene/EtOH. 

More recent examples have employed a milder reagent system, triphenyl-phosphine and dibromotetrachloroethane to generate a bromo-oxazoline, which is subsequently dehydrohalogenated. Wipf and Lim utilized their method to transform intermediate 11 into the 2,4-disubstituted system of (+)-Hennoxazole k Subsequently, Morwick and coworkers reported a generalized approach to 2,4-disubstituted oxazoles from amino acids using a similar reagent combination, triphenylphosphine and hexachloroethane. ... 

A similar situation occurs in trivalent phosphorus compounds, or phosphines. It turns out, though, that inversion at phosphorus is substantially slower than Inversion at nitrogen, so stable chiral phosphines can be isolated. (R)- and (5)-metbylpropylphenylphosphine, for example, are configurationally stable for several hours at 100 °C. We ll see the Importance of phosphine chirality in Section 26.7 in connection with the synthesis of chiral amino adds. 

Calcium-binding proteins, 6, 564, 572, 596 intestinal, 6, 576 structure, 6, 573 Calcium carbonate calcium deposition as, 6, 597 Calcium complexes acetylacetone, 2, 372 amides, 2,164 amino acids, 3, 33 arsine oxides, 3, 9 biology, 6, 549 bipyridyl, 3, 13 crown ethers, 3, 39 dimethylphthalate, 3, 16 enzyme stabilization, 6, 549 hydrates, 3, 7 ionophores, 3, 66 malonic acid, 2, 444 peptides, 3, 33 phosphines, 3, 9 phthalocyanines, 2,863 porphyrins, 2, 820 proteins, 2, 770 pyridine oxide, 3,9 Schiff bases, 3, 29 urea, 3, 9... 

A similar microwave-assisted cyclization in the presence of ammonium acetate of an a-ketoamide, obtained by acylation of an a-aminoketone, was recently described for the synthesis of the antifungal agent Nortopsedin D [46]. The problem of the instabiUty of the a-amino ketones was successfully resolved by in situ acylation of the amine derived from Staudinger reaction of the azide 50 with a phosphine (Scheme 16). This ketoamide was... 

Other cyclizations at phosphorus have been observed when certain phosphinates were used in the acid-catalyzed Mannich reaction. As observed previously with various phosphonous acid derivatives, reaction of aliphatic phosphinic acids with primary amines favored the formation of 2 1 adducts (73). Thus, glycine and other a-amino acids reacted under the typical conditions with excess formaldehyde and alkyl phosphonous acids to give the bis-phosphinylmethyl adducts 125. 

Also covered by this review are those compounds bearing two or three phosphane units at the same N atom, that is those derived from (H2P)2NH (N-phosphino phosphinous amide in CAS nomenclature) and from (H2P)3N, NJsl-bis(phosphino) phosphinous amide, but not those bearing more than one amino... 

This chapter will also deal with compounds containing two or three phosphinous amide units, which, for simpUcity, will be named here as bis(amino-phosphanes) or tris(aminophosphanes) but not with phosphinous amides containing other additional organophosphorus functionaUties as, for instance, the so-called aminophosphine phosphinites (AMMP), which have been the subject of increasing attention in the Uterature dealing with catalytic asymmetric transformations and have been treated in other reviews [2,3]. 

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