Phosphine hgands amino phosphines

An interesting approach to develop an asymmetric allylic alkylation catalyst by using a peptide-based phosphine hgand was examined by Gilbertson (Scheme 3.70) [135]. Phosphine-sulfide amino acid 211 was incorporated into a peptide sequence on a polymer support After reduchon of the phosphine sulfide to phosphine, the polymer-supported pephde sequence having phosphine-(support-Gly-Pps-D-Ala-Pro-Pps-D-Ala-Ac) was prepared. The complex of the peptide with Pd was uhhzed for the asymmetric addition of dimethyl malonate 202 to 3-acetoxycy-clopentene 212 to give 213 in 59% yield and 66% ee. 

Asymmetric intermolecular Mizoroki—Heck reaction From phosphine/ phosphinite-nitrogen to phosphite-nitrogen hgands 12IJC572. Asymmetric palladium-catalyzed intramolecular Wacker-type cycliza-tions of unsaturated alcohols and amino alcohols to give O- and N-het-erocycles 13MOL6173. 

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