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Phenylephrine A

Phenylephrine a, adrenergic vasoconstriction ionotropic effects may occur, via myocardial ui adrenoceptors Critical maintenance of perfusion Increased afterload decreased peripheral perfusion... [Pg.208]

Phenylephrine, a selective a i-agonist, has a rapid onset, short duration, and primary vascular effects, making it an attractive agent in the management of hypotension associated with septic shock. The limited available information suggests that it can increase blood pressure in fluid-resuscitated patients, and it does not appear to impair cardiac or renal function. Phenylephrine appears useful when tachycardia limits the use of other vasopressors. [Pg.2140]

Fig. 9.28. Cytosolic Ca" waves in hepatocytes (Rooney et al, 1991). In response to phenylephrine, a wave of Ca is seen to propagate from the right to the left extremity of a single cell the time t (in s) is indicated for successive snapshots of the intracellular spatial Ca " distribution. Fig. 9.28. Cytosolic Ca" waves in hepatocytes (Rooney et al, 1991). In response to phenylephrine, a wave of Ca is seen to propagate from the right to the left extremity of a single cell the time t (in s) is indicated for successive snapshots of the intracellular spatial Ca " distribution.
Phenylephrine, a pure alpha receptor stimulator, has not been demonstrated to be more effective than epinephrine in treating open-angle glaucoma. When administered in combination with miotics, phenylephrine exhibits a competitive effect. [Pg.366]

The analysis of a pharmaceutical preparation for pheniramine maleate and phenylephrine hydrochloride is described in this experiment. [Pg.448]

Phenylephrine (90) is a selective receptor agonist (+)-niguldipine (91) is a selective antagonist for the receptor. Pra2osin (92) and 5-methylurapidil (93) are nonselective a -receptor antagonists. CEC can differentiate receptors from the other receptors. Pra2osin has low and high affinity for and receptors, respectively. [Pg.535]

Phenylephrine. Phenylephrine hydrochloride is an a -adrenoceptor agonist. Phenylephrine produces powerful vasoconstrictor and hypertensive responses. This results in baroreceptor activation of a reflex bradycardia and thus is useful in the treatment of supraventricular tachyarrhythmias. Unlike epinephrine [51-43-4] the actions of which are relatively transient, phenylephrine responses are more sustained (20 min after iv dosing and 50 min after subcutaneous dosing) (86). [Pg.120]

Lion of action. The largest use of this drug, however, depends on its vasoconstricting action phenylephrine is used extensively as a nasal decongestant due to its ability to constrict the blood vessels in mucous tissue on local application. In one published... [Pg.63]

Levonordefrine Mephentermine Metaramino1 Methamphetamine A-Norepinephrine Phenylephrine... [Pg.433]

A large number of diugs interfere with the smooth muscle contraction. These compounds lower blood pressure and are referred to as antihypertensive. In this section, only those coumpounds will be mentioned that have a direct effect on smooth muscle tone. Phenylephrine is an agonist on most smooth muscles and activates ax adrenoceptors. Carbachol is an agonist on some smooth muscles and activates contraction through muscarinic receptors. Blockers of the ax-adrenoceptors such as prazosin and urapidil are competitive inhibitors of the ax-receptor in vascular and bladder smooth muscle. Phenoxybenzamine is an ineversible blocker of ax receptors and phentol-amine blocks ax and a2 receptors. Ca2+ channel blockers such as the dihydropyiidines, phenylalkyla-mines and benzothiazepines lower smooth muscle tone by blocking the L-type calcium channel. [Pg.1145]

Dynex Tablets—pseudoephedrine, guaifenesin Ed A Hist Tablets—phenylephrine HC1, chloqiheni-rarnine maleate... [Pg.681]

AH-Chew Tablets—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate D.A. Chewable Tablets—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate Dallergy Syrup or Tablets—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate Dehistine Syrup—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate Extendryl Syrup—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate Pannaz Tablets or Syrup—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate Rescon-MX Tablets—phenylephrine HC1, chlorpheniramine maleate, methscopolamine nitrate... [Pg.682]

The more useful types of chirally active bonded phases are those based on the cyclodextrins. There are a number of different types available, some of which have both dispersive or polar groups bonded close to the chirally active sites to permit mixed interactions to occur. This emphasizes the basic entropic differences between the two isomers being separated. A range of such products is available from ASTEC Inc. and a separation of the d and / isomers of scopolamine and phenylephrine are shown in figure 4. The separations were carried out on a cyclodextrin bonded phase (CYCLOBOND 1 Ac) that had been acetylated to provide semi-polar interacting groups in close proximity to the chiral centers of the cyclodextrin. The column was 25 cm long, 4.6 mm in diameter and packed with silica based spherical bonded phase particles 5pm in diameter. Most of the columns supplied by ASTEC Inc. have these dimensions and, consequently, provide a... [Pg.291]

The Separation of the Isomers of Scopolamine and Phenylephrine on a Cyclodextrin Bonded Phase... [Pg.292]

FIG. 17 Chemical structures of (a) epinephrine hydrochloride, (b) dopamine hydrochloride, (c) isoproterenol hydrochloride, (d) phenylephrine hydrochloride, (e) tolazoline hydrochloride, (f) oxyprenolol hydrochloride, (g) alprenolol hydrochloride, and (h) propranolol hydrochloride. [Pg.714]

Figure 5 Separation of pharmaceuticals, including amines, on strong cation exchange. Column 0.46 x 15 cm Merckosorb SI-60-SCX, 5 p. Eluent 50 mM aqueous ammonium formate-10% ethanol, pH 4.8. Flow 1 ml/min. Temperature 50°C. The peaks are (1) aspirin, (2) paracetamol, (3) phenacetin, (4) caffeine, (5) phenylephrine, (6) salbutamol. (Reproduced with permission of Elsevier Science from Cox, G. B., Loscombe, C. R., Slucutt, M. J., Sugden, K., and Upheld, J. A., /. Chromatogr., 117, 269, 1976). Figure 5 Separation of pharmaceuticals, including amines, on strong cation exchange. Column 0.46 x 15 cm Merckosorb SI-60-SCX, 5 p. Eluent 50 mM aqueous ammonium formate-10% ethanol, pH 4.8. Flow 1 ml/min. Temperature 50°C. The peaks are (1) aspirin, (2) paracetamol, (3) phenacetin, (4) caffeine, (5) phenylephrine, (6) salbutamol. (Reproduced with permission of Elsevier Science from Cox, G. B., Loscombe, C. R., Slucutt, M. J., Sugden, K., and Upheld, J. A., /. Chromatogr., 117, 269, 1976).

See other pages where Phenylephrine A is mentioned: [Pg.962]    [Pg.962]    [Pg.616]    [Pg.364]    [Pg.969]    [Pg.357]    [Pg.785]    [Pg.785]    [Pg.397]    [Pg.908]    [Pg.521]    [Pg.908]    [Pg.976]    [Pg.902]    [Pg.84]    [Pg.421]    [Pg.926]    [Pg.962]    [Pg.962]    [Pg.616]    [Pg.364]    [Pg.969]    [Pg.357]    [Pg.785]    [Pg.785]    [Pg.397]    [Pg.908]    [Pg.521]    [Pg.908]    [Pg.976]    [Pg.902]    [Pg.84]    [Pg.421]    [Pg.926]    [Pg.359]    [Pg.64]    [Pg.20]    [Pg.20]    [Pg.1755]    [Pg.323]    [Pg.200]    [Pg.329]    [Pg.332]    [Pg.294]    [Pg.169]    [Pg.713]    [Pg.164]    [Pg.229]    [Pg.575]    [Pg.797]   
See also in sourсe #XX -- [ Pg.1148 ]




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Phenylephrin

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