Nasal decongestant

Tetrahydro2oline [84-22-0] 2-(l,2,3,4-tetrahydro-l-naphthyl)2-imida2olin, (Tysine, Visine) (40), a sympathomimetic and nasal decongestant, is made by the condensation of 1,2,3,4-tetrahydro-l-naphthoic acid or its methyl ester with 1,2-ethylenediamine. 

Lion of action. The largest use of this drug, however, depends on its vasoconstricting action phenylephrine is used extensively as a nasal decongestant due to its ability to constrict the blood vessels in mucous tissue on local application. In one published... 

Therapeutic Function Nasal decongestant Chemical Name 4-methvl-2-hexylamine carbonate Common Name —... 

F Partial agonist Antagonist Nasal decongestion, glaucoma, shock, cardiopulmonary resuscitation... 

Hypotension and allergic disorders, asthma 25/mg—50 mg IM, SO, or IV topical nasal decongestant instill in each nostril q4h... 

Do not use any nonprescription drug (eg, cold or flu preparations or nasal decongestants) unless use of a specific drug has been approved by the primary care provider. 

SUM MARY DRUG TABLE SYSTEM 1C AND TOPICAL NASAL DECONGESTANTS... 

Additive sympathomimetic effects may develop when decongestants are administered with other sympathomimetic drug s (see Chap. 22). Use of the nasal decongestants with the MAOIs may cause hypertensive crisis. Use of a decongestant with beta-adrenergic blocking dragp may cause hypertension or bradycardia. When ephedrine is administered with theophylline, the patient is at increased risk for theophylline toxicity. 

The expected outcomes of die patient may include an optimal response to therapy and an understanding of die use of die nasal decongestants. 

Understand tiiat overuse of topical nasal decongestants can make the symptoms worse ... 

Discuss important teaching points that should be included in developing a teaching plan for a patient taking a nasal decongestant. Determine what teaching points would be the most important. Provide a rationale for your answer. 

Menthol, also known as peppermint oil, is used widely in toothpastes, mouthwashes, gum, sore-throat lozenges, lip balms, and nasal decongestants. For topical analgesic use, it is available in creams, lotions, ointment, and patches. The patches can be trimmed to fit the affected area. 

Topical intranasal decongestants (e.g., oxymetolazine, xylome-tolazine, phenylephrine, and naphazoline) are OTC options that provide prompt relief of nasal congestion. Nasal decongestants are dosed multiple times daily.15 Tachyphylaxis, rebound congestion, and rhinitis medicamentosa may occur with chronic use therefore, use should be limited to 3 to 5 days.8,12 These may be used 5 to 10 minutes before administration of intranasal corticosteroids in patients with blocked nasal passages.15... 

Ephedrine An amphetamine-like drug used as a nasal decongestant. 

Nasal decongestant sprays such as phenylephrine and oxymetazoline that reduce inflammation by vasoconstriction are often used in sinusitis. Use should be limited to the recommended duration of the product to prevent rebound congestion. Oral decongestants may also aid in nasal or sinus patency. To reduce mucociliary function, irrigation of the nasal cavity with saline and steam inhalation may be used to increase mucosal moisture, and mucolytics (e.g., guaifenesin) maybe used to decrease the viscosity of nasal secretions. Antihistamines should not be used for acute bacterial sinusitis in view of their anticholinergic effects that can dry mucosa and disturb clearance of mucosal secretions. 

Phenylpropylamine (e.g. Proin) Nasal decongestant, weight control Hemorrhagic stroke 2000 [55,56]... 

Methamphetamine is a potent stimulant that was first synthesized by a Japanese scientist in the early 1900s as an analogue of amphetamine for use as a nasal decongestant, antiasthma drug, and weight loss aid. However, it was not used commercially until the 1940s when it was manufactured and marketed as Methedrine by the pharmaceutical company Burroughs Wellcome. 

Ibuprofen, pseudoephedrine and chlorpheniramine are the drag substances have an effect as antihistaminic, nasal decongestant and antiinflammatory, respectively. The combination of these drags, is effective in cold, sinus and flu symptoms and used for upper respiratory infections. Nipagen (methylparaben) is widely used as... 

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