Pharmaceutical packaging blister packages

Lastly, another way to approach the decision about which tool to choose can be addressed from the perspective of which package type from which oxygen levels are desired. For the sake of brevity, only the three most common pharmaceutical packaging (plastic bottles, glass vials/ampoules, blister packages) configurations are discussed. 

Other than being used to pack solid dose medication, blisters or bubble packs, as they are often known, may find further applications in pharmaceutical packaging. These may be as a protective overwrap against physical damage, to prevent ingress or egress, to aid display or to act as a tamper-evident/tamper-resistant feature (i.e. packs which are not involved with the solid dosage form). 

Applications aluminum foil coating, adhesives, blisters, credit cards, flooring, inks, mastics, paints, pharmaceutical packaging, printing inks, records, rigid sheets, sealers, strippable coatings, varnishes ... 

Figure 10-26 Example of Blister Pack Pharmaceutical Packaging for Consumer Applications...

Blister packages for pharmaceuticals consist of two basic packaging components lidding material and... 

H. Liu. Classifications of PYC for pharmaceutical blister packaging using pattern recognition techniques. Ph.D. dissertation, Rutgers University, New Brunswick, NJ, 1998. 

Blisters and dosage packs for pharmaceuticals and medicines, single dose medication packaging, shatterproof bottles and jars. .. 

Although metallic packaging is also used for pharmaceutical products, its use is restricted to blisters supports, which have no contact with the formulation, and tubes for ointments. 

Major application for PCTPE is in specialty films for packaging in applications where there are high moisture barrier demands, such as pharmaceutical blister... 

Processing PCTFE is by the conventional methods (extrusion, injection, etc.) processing temperatures are high, and any degradation of PCTFE can cause severe corrosion and environmental problems. Applications include wire and cable insulation, electronic flexible printed circuits, packaging material (transparent film and sheet), pharmaceutical industry in particular strip and blister packs for tablets and capsules, etc. In the chemical industry, used as gaskets, 0-rings, valve seats, chemical tank liners, etc. 

PP is often combined with PE to achieve desirable properties from both compounds. Commonly selected for its strength, resiliency, and gas/water impermeability, PP commonly constitutes closures and seals. Bags for packaging intravenous fluids are often manufactured from PP stock. Although not commonly utilized in the U.S.A., PP can also be used as a moisture barrier as one layer of a blister pack film. As with all plastics, though, manufacturers of PP should assure users that no additives leach out of the PP resin into the pharmaceutical preparation and quality testing specifications are contained in the USPp ... 

The most common applications of paper, paper-board, and cardboard are in blister lidding stock and in over-the-counter (OTC) outer packaging. Because paper, paperboard, and cardboard offer virtually no moisture or gas barrier, they are typically part of the secondary pharmaceutical container. To provide additional protection, paper can be laminated or coated with a variety of materials. More commonly, when paper is involved in critical packaging functions, it is the only one component of a multicomponent system that offers optimal environmental protection to the drug environment. ... 

An NIR spectroscopic method to identify pharmaceutically active and inactive (placebo) clinical dosage forms was recently developed.Typically, the dosage form is packaged with its placebo in the same blister pack. The purpose of the NIR identification method was to identify, nondestructively and rapidly, the four forms in the blister pack. The method was developed to create and validate a one-time-use library of the spectra of clinical dosage forms prepared for double-blind clinical trials. 

For some excipients, the global acceptability of some packaging materials varies from country to country. This can often stem from environmental concerns and the negative impact from the need to dispose of packaging waste. For example, polyvinyl chloride (PVC) is used widely to manufacture bottles and blisters for pharmaceutical products, but there is a growing concern about its safe use and disposal in some countries (Hansen 1999). Incineration is the preferred method of disposal for PVC, with the downside that it emits toxic gases. Materials that are readily biodegradable, or that can be recycled, are preferred. This is not always possible with some types of synthetic materials. 

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