Peritonitis evaluation

Evaluate the patient for complications associated with dialysis. Does the patient develop hypotension or cramps during hemodialysis Does the patient have symptoms consistent with peritonitis or a catheter infection ... 

In 1989, we showed [142] that the Fe2+(rutin)2 complex is a more effective inhibitor than rutin of asbestos-induced erythrocyte hemolysis and asbestos-stimulated oxygen radical production by rat peritoneal macrophages. Later on, to evaluate the mechanisms of antioxidant activities of iron rutin and copper-rutin complexes, we compared the effects of these complexes on iron-dependent liposomal and microsomal lipid peroxidation [165], It was found that the iron rutin complex was by two to three times a more efficient inhibitor of liposomal peroxidation than the copper-rutin complex, while the opposite tendency was observed in NADPH-dependent microsomal peroxidation. On the other hand, the copper rutin complex was much more effective than the iron rutin complex in the suppression of microsomal superoxide production, indicating that the copper rutin complex indeed acquired additional SOD-dismuting activity because superoxide is an initiator of NADPH-dependent... 

Intracavitary administration of various agents has been used for patients with malignant pleural or peritoneal effusions. Intraperitoneal instillations of cisplatin, etoposide, bleomycin, 5-fluorouracil, and interferon are well tolerated and are being evaluated in patients with ovarian carcinomas, in whom the tumor is frequently restricted to the peritoneal cavity. 

A large multicenter pivotal phase II study was performed to evaluate the efficacy of rituximab in the treatment of relapsed low-grade or follicular CD20(+) B-cell NHL (171). A total of 166 patients with small lymphocytic (n= 33), follicular small cleaved (n = 67), follicular mixed (n= 53), follicular large-cell (n = 10), or low-grade variant (n = 3) NHL were enrolled at 31 centers. Patients with bulky disease (>10 cm), pleural or peritoneal involvement, CNS lymphoma, AIDS-related lymphoma, CLL or leukemic component (more than 5,000 lymphocytes/pl) were excluded. Rituximab was again administered intravenously at 375 mg/m2 weekly for four doses. The overall response rate, which was the primary study end point, was... 

Iridoids represent a class of 941 known cyclopentano[c]pyran monoterpenoids [3] and have been reported with hepatoprotective, choleretic, vasoconstriction, anti-viral, anti-microbial, anti-inflammatory and analgesic activities. Seven iridoid glycosides, isolated from Scrophularia scorodonia L. (Scrophulariaceae), have been evaluated for effects on PGE2, and LTC4 production using calcium ionophore stimulated mouse peritoneal... 

In Hoult s report, sixteen natural and synthetic coumarins were evaluated in rat peritoneal exudate leukocytes for the impact on production of throboxane B2 and leukotriene B4. (Table 4.) Four coumarins exhibited... 

Patupilone (epothilone B, EPO906) 29 (Novartis) is being evaluated in a Phase III trial for the treatment of patients with ovarian, primary fallopian or peritoneal cancer.191,196,197 Patupilone (then called epothilone B) 29 was first reported by Hofle and co-workers198 200 31 from the myxobacterium Sorangium cellulosum in a 1991 patent application and epothilones were shown by workers at Merck in 1995 to have tubulin-stabilising activity similar to that of paclitaxel 60.31 Ixabepilone 28, which is the semi-synthetic lactam derivative of patupilone 29, was the first epothilone derivative approved (October 2007) for the treatment of breast cancer. 

Intraperitoneal Administration The potential of PEGylated liposomes administered intraperitoneally has been evaluated for cancers located in the peritoneal cavity. For example, Syrigos et al. [238] studied the biodistribution of indium ( Relabeled PEGylated liposomes [Hydrogenated soya PC (HSPC)/ChoPPEG-DSPE] compared to free mIn via either i.p. or i.v. route to non-tumor bearing mice. The AUC of In-PEG liposomes was 74-fold higher than that of free indium. The relative ratio of the AUCs (RR-AUCs) for i.p. versus i.v. administration for peritoneum was 1.36 [423.6 vs. 311.3% individual dose (ID) g/h]. The blood AUC values for i.p. and... 

Brady, P.G., Peebles, M., Goldschmld, S. Role of laparoscopy in the evaluation of patients with suspected hepatic or peritoneal mahgnancy. Gastrointest. Endosc. 1991 37 27—30... 

Bhuva, M., Ganger, D., Jensen, D. Spontaneous bacterial peritonitis an update on evaluation, management, and prevention. Amer. X Med. 1994 97 169-175... 

---