Glycosides iridoid

The solubility of iridoids depends on their state (free, glycosylated, acetylated), but usually they are extracted with polar solvents methanol, ethanol, aqueous alcohols, and rarely acetone. Iridoid glycosides are more or less stable some of them are very sensitive to acids and alkalis. Some iridoid glycosides such as aucubin suffer color modification after chemical or enzymatic hydrolysis they give first a blue to green... 

Konoshima, T. et al.. Cancer chemopreventive activity of an iridoid glycoside, 8-acetylharpagide, fvom Ajuga decumbens. Cancer I tt., 157, 87, 2000. 

Suomi, J., Wiedmer, S. K., Jussila, M., and Riekkola, M. L. (2002). Analysis of eleven iridoid glycosides by micellar electrokinetic capillary chromatography (MECC) and screening of plant samples by partial filling (MECC)-electrospray ionization mass spectrometry.. Chromatogr. A 970, 287-296. 

Plant 3-glucosidases also cause hydrolysis of iridoid glycosides, and are highly specific in activity (6). Several insect species that are able to tolerate iridoids have been found to contain inhibitory 3-glucosidases. These and other systems are under continuing investigation in this laboratory. 

Lahloub, M.F., Flavonoid, phenylpropanoid and iridoid glycosides of Linaria haelava (Forssk.) Dik, Mansoura J. Pharm. Sci., 8, 78, 1992. 

Vanderlei MF, Silva MS, Gottlieb HF, Braz-Filho R. Iridoids and Triterpenes from Hi-matanthus phagedaenica the Complete Assignment of the Proton and Carbon-13 NMR Spectra of Two Iridoid Glycosides. Journal of the Brazilian Chemical Society 1991 2(2) 51-55. 

Shen YC, Chem CH. /Yllaneroside and Bioactive Iridoid Glycosides from Allamanda neriifolia. Taiwan Yaoxue Zazhi 1986 38(4) 203-213. 

Bobbitt J.M., Segebarth K.P. The Iridoid Glycosides and Similar Substances. In Bat-tersby A.R. and Taylor W.I. (eds.) Cyclopentanoid Terpene Derivatives. New York Marcel Dekker 1969. p25-31. 

Devil s claw (Harpagophytum procumbens) Harpagophytum procum-bens is native to South Africa, Namibia and Madagascar, and traditionally used in the treatment of osteoarthritis, rheumatoid arthritis, indigestion and low back pain. This plant contains 0.5-3 per cent iridoid glycosides. 

Picrorhiza has been used widely in India, and no significant adverse reactions have been reported to date. The oral LD50 of Picrorhiza iridoid glycosides (known as kutkin ) is greater than 2600mg/kg in rats. 

N.A. Iridoid glycosides, verbenalin, saponins, tannins.100 102 123 Mild effect on the involuntary nervous system, which governs the digestive system. 

N.A. Iridoid glycosides, flavonol glycosides, coumarins, phenolic acids, sterols, triterpenoids, tannins." Stimulate digestive secretions, treat fluid retention, scabies, and fever. 

Scrophularia ningpoensis Hemsl. China Scrophularin, iridoid glycosides, 8-(0-methyl-p-coumaroyl)-harpagide, harpagoside, essential oils, flavonoids, p-methoxylcinnamic acid.33 Lower blood pressure and blood sugar. A health strengthening agent. 

Bowers, M. D. and Stamp, N. E. (1997). Fate of host-plant iridoid glycosides in... 

Kasai R, Katagiri M, Ohtani K, Yamasaki K, Yang C-R, Tanaka O (1994) Iridoid Glycosides from Phlomis younghusbandii Roots. Phytochemistry 36 967... 

Of biochemical interest is the presence of quite significant amounts (up to 5%) of the iridoid glycoside loganin (see page 188) in the fruit pulp of Strychnos nux-vomica. This compound is, of course, an intermediate in the biosynthesis of strychnine and other terpenoid indole alkaloids. 

B. Gering, P. Junior, and M. Wichtl, Iridoid glycosides from Penstemon confertus, Phytochemistry, 26 (1987) 3011-3013. 

Ajuga decumbens (Labiatae) (flowering whole plant) has been used as a folk medicine for anti-inflammatory, anti-tussive and expectorant effects in China and Japan. 8-Acetylharpagide (Mo37), an iridoid glycoside... 

Oleuropein (seco-iridoid glycoside) Olea europaea (Oleaceae) ACE (38% inhibition at 300 UM) [76]... 

Iridoids represent a class of 941 known cyclopentano[c]pyran monoterpenoids [3] and have been reported with hepatoprotective, choleretic, vasoconstriction, anti-viral, anti-microbial, anti-inflammatory and analgesic activities. Seven iridoid glycosides, isolated from Scrophularia scorodonia L. (Scrophulariaceae), have been evaluated for effects on PGE2, and LTC4 production using calcium ionophore stimulated mouse peritoneal... 

R = Ac) from Barleria prionitis.189 Interest continues in iridoid glycosides from Valerianaceae. Three examples are now known with glucose linked to the C-ll rather than the C-l hydroxy-group they are patrinoside (100) from Patrinia scabiosaefolia,190 the previously unreported villoside (101),191 and valerosidate... 

Four new alkaloids, daphnezomines P-S (S2-SS) have been isolated from the fruits of D. humile and daphnezomines P (52) and Q (S3) were the first daphniphyllum alkaloids with an iridoid glycoside moiety [78]. 

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