Peptostreptococcus infection

Infections caused by these injuries are most often caused by the normal oral flora, which includes both aerobic and anaerobic microorganisms. The most frequent aerobic organisms are Streptococcus spp., Staphylococcus spp., and Eikenella corrodens. The most common anaerobic organisms are Fusobacterium, Prevotella, Porphyromonas, and Peptostreptococcus spp. 

Lincosamides (lincomycin and clindamycin) are representatives of a very small group of drugs synthesized up of an amino acid bound to an amino sugar. Lincosamides bind with the 50 S ribosomal subunit of bacteria and inhibit protein synthesis. They also inhibit pep-tidyltransferase action. Lincosamides are bacteriostatic antibiotics however, when they reach a certain level in the plasma, they also exhibit bactericidal action against some bacteria. Lincosamides are highly active against anaerobic infections such as Peptococcus, Peptostreptococcus, Actinomyces, Propionibacterium, and Clostridium fringens, a few types of Peptococcus and Clostridium. 

Intra-abdominal infections Complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacterioides fragilis, Bacterioides thetaiotaomicron, and Peptostreptococcus sp. 

Intra-abdominal Infections - Enterococcus faecalis, S. aureus (penicillinase-producing), Staphylococcus epidermidis, E. coli, Klebsiella sp., Enterobacter sp., Proteus sp., M. morganii, P. aeruginosa, Citrobactersp., Clostridium sp., Bacteroides sp. including Bacteroides fragilis, Fusobacterium sp. Peptococcus sp., Peptostreptococcus sp., Eubacterium sp., Proplonibacterium sp.. Bifidobacterium sp. 

Gynecologic infections - Gynecologic infections, including postpartum endomyometritis, caused by group D streptococcus such as E. faecalis, E. coli] K. pneumoniae] B. intermedius, Peptostreptococcus sp. 

Compiicated intra-abdominai infections Caused by Escherichia coii, Ciostridium ciostridioforme, Eubacterium ientum, Peptostreptococcus sp., Bacteroides fragiiis, B. distasonis, B. ovatus, B. thetaiotaomicron, or B. uniformis. 

Compiicated skin and skin structure infections Caused by Staphyiococcus aureus (methicillin-susceptible strains only). Streptococcus pyogenes, E. coii, or Peptostreptococcus sp. 

Skin and skin structure infections - Caused by Bacteroides sp. including the B. fragilis group, Clostridium sp., Peptococcus sp., Peptostreptococcus niger, and Fusobacterium sp. 

A 35-year-old man was given vancomycin (1.5 g bd) for a wound infection with a coagulase-negative staphylococcus, a peptostreptococcus, and a corjmeform Grampositive bacillus. On day 37 hi white blood cell count was 2.8 x 10 /1 (baseline 5.2) with a low neutrophil count (0.5 x 10 /1). Vancomycin was withdrawn and 2 days later he was given teicoplanin 400 mg/day, by which time the cell count had increased to 3.5 x 10 /1, neutrophils 0.9 x 10 /1. On day 45, the total white cell count was 4.9 x 10 /1, neutrophils 2.3 x 10 /1. Teicoplanin was continued for 1 month, and the white cell count remained normal. 

Azithromycin (Zithromax) Mycoplasma, Ureaplasma, Treponema, Chlamydia, Borrelia burgdorferi. Gram pos except Corynebacterium Listeria. Gram negatives except Neisseria Pasteurella. Anaerobes Clostridium, B. bivius, Peptostreptococcus. Same as clarithromycin plus uncomplicated Chlamydia infections. 

Brenn et al. [ 153] compared the efficacy of antibiotics commonly used in dental and oral clinical practice in application to the bacteria most frequently isolated in odontogenic infections (S. viridans, Peptostreptococcus spp, Prevotella intermedia, Porphyromona gingivalis and Fusobacterium nucleatum) based on pharmacokinetic and pharmacodynamic (PK/PD) analyses (effect of the human body upon the drug, reflected by the plasma concentration profile-pharmacokinetics, and the effect of the drug upon the body, as defined by the minimum inhibitory concentration, or MIC-pharmacodynamics). Antibiotics commonly used in dental practice, such as erythromycin, metronidazole or azithromycin, were found to be ineffective in apphcation in over 30% of the strains (39.1%, 50.5% and 33.2%, respectively) [154]. 

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