Fusobacterium nucleatum

Kapatral, V. Anderson, I. Ivanova, N. et al. Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum strain ATCC 25586. J. Bacteriol., 184, 2005-2018 (2002)... 

A similar distribution of fatty acids has also been detected in lipid A of other bacteria (Fig. 5). Thus, in Fusobacterium nucleatum, 2 moles of (R)-3-OH-14 0 are ester-bound, one of which is 3-O-acylated by 14 0. In amide linkage, (R)-3-0(14 0)-16 0 is present. In Vibrio cholerae, a dimer of (R)-3-OH-12 0 is bound as an ester while (R)-3-0-(14 0)-14 0 and (R)-3-0-(16 0)-14 0 are amide-linked. The lipid A component of Chromobacterium violaceum possesses 2 moles of (R)-3-OH-10 0 in ester linkage. The amide-bound acyl groups are represented by (R)-3-0H-12 0 residues which are 3-0-acylated by 12 0 and (S)-2-OH-12 0. In P. mirabilis, 3-0H-14 0 is, like in Salmonella, ester-and amide-bound. In this case, however, exclusively 14 0 substitutes the 3-hydroxyl groups of both 0- and N-linked 3-OH-14 0. 

Fusobacterium nucleatum Oral cavity microbe Label-free Metabolic pathway analysis (167)... 

Scoular, A., Corcoran, G.D., Malin, A., Evans, BA., Davies, A., Miller, R.F. Fusobacterium nucleatum bacteraemia with multiple hver... 

Takahashi, N., Saito, K., Schachtele, C.-F., and Yamada, T. 1997. Acid tolerance and acid-neutralizing activity of Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum. Oral Microbiology and Immunology 12 323-328. 

Fig. 13 2 Common bacteria of plaque. Slides show typical gram stain for (a) viridans streptococci (b) fch nomyces naeslundii, previously, viscostts (c) Eikenella corrodens, and (d) Fusobacterium nucleatum (From Public Health Image Library (PHIL) at the CDC - Bacteria Site http //phil.cdc. go v/phil/home. asp)...

PLP-dependent desulfhydrases necessarily show very similar mechanisms, but often come from independent evolutionary lineages. For example, although most bacterial L-cysteine desulfhydrases are fold-type I enzymes belonging to the same evolutionary branch as cystathionine f3- and 7-lyases, L-cysteine desulfhydrase from Fusobacterium nucleatum is a member of the fold-type II group and its closest sequence homologue is a cysteine synthase. D-cysteine desulfhydrase from E. coli is also a fold-type II enzyme not strictly related to other desulfhydrases but resembling instead an ACC deaminase. ... 

Lanthionine, a monosulphated analogue of diaminopimelic acid, has been isolated from the peptidoglycan of Fusobacterium nucleatum, which contained all the other normal constituents, with the exception of diaminopimelic acid. ... 

Brenn et al. [ 153] compared the efficacy of antibiotics commonly used in dental and oral clinical practice in application to the bacteria most frequently isolated in odontogenic infections (S. viridans, Peptostreptococcus spp, Prevotella intermedia, Porphyromona gingivalis and Fusobacterium nucleatum) based on pharmacokinetic and pharmacodynamic (PK/PD) analyses (effect of the human body upon the drug, reflected by the plasma concentration profile-pharmacokinetics, and the effect of the drug upon the body, as defined by the minimum inhibitory concentration, or MIC-pharmacodynamics). Antibiotics commonly used in dental practice, such as erythromycin, metronidazole or azithromycin, were found to be ineffective in apphcation in over 30% of the strains (39.1%, 50.5% and 33.2%, respectively) [154]. 

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