Structure peptide

As m most aspects of chemistry and biochemistry structure is the key to function We 11 explore the structure of proteins by first concentrating on their fundamental building block units the a ammo acids Then after developing the principles of peptide structure we 11 see how the insights gamed from these smaller molecules aid our under standing of proteins... 

An example is shown in Figure 7 for the case of the coil-to-helix transition. The endpoints of the calculation are an unstructured coil Tr and helix rp. Intermediate peptide structures correspond to transition intermediates defining the pathway l(r). 

Bella, J., Brodsky, B., Berman, H.M. Hydration structure of a collagen peptide. Structure 3 893-906, 1995. 

By agreement, peptide structures aie written so that the ffluino group (as H3N— or H2N—) is at the left and the caiboxyl group (as CO2 or COiFl) is at the right. The... 

There are several levels of peptide structure. The primary structure is the amino acid sequence plus any disulfide links. With the 20 anino acids of Table 27.1 as building blocks, 20 dipeptides, 20 tripeptides, 20" tetrapeptides, and so on, are possible. Given a peptide of unknown structure, how do we determine its anino acid sequence ... 

A unique family of O-linked glycoproteins permits fish to live in the icy seawater of the Arctic and Antarctic regions where water temperature may reach as low as — 1.9°C. Antifreeze glycoproteins (AFGPs) are found in the blood of nearly all Antarctic fish and at least five Arctic fish. These glycoproteins have the peptide structure... 

Cerda-Reverter JM, Larhammar D (2000) Neuropeptide Y family of peptides structure, anatomical expression, function, and molecular evolution. Biochem Cell Biol 78 371-392... 

In the strict sense, opiates are drugs which are derived from opium and include the natural products morphine, codeine, thebaine and many semi-synthetic congeners derived from them. In the wider sense, opiates are morphine-like drugs with non-peptidic structures. The old term opiates is now more and more replaced by the term opioids which applies to any substance, whether endogenous or synthetic, pqrtidic or non-peptidic, that produces morphine-like effects through an action on opioid receptors. 

Hoveyda and coworkers [142] developed the Cu-catalyzed allylic substitutions of phosphonate derivatives with pyridinyl peptide structures as efficient ligands. The structure of the ligands was chosen through synthesis, and analysis of libraries. Optimized compounds were used as ligands for the... 

These free energies determine the critical concentrations for observing each peptide structure. In very dilute conditions, this class of peptides exist as random coil monomers in conformational flux. Above a critical concentration, C( pg, the concentration of monomer remains constant and formation of tapes occurs ... 

His residues in the peptide sequence are fundamental for Ni11 ion interactions with peptides. When the His residue is relatively distant from the N terminus, it may compete as a primary ligation site with the N-terminal amino nitrogen. However, even the higher number of His residues inserted inside the peptide sequence may be not able to compete with the albumin-like N terminus, unless the specific peptide structure is established. 

Burton PS, RA Conradi, AR Hilgers, NFH Ho, LL Maggiora. (1992). The relationship between peptide structure and transport across epithelial cell monolayers. J Controlled Release 19 87-98. 

Conradi RA, AR Hilgers, NFH HO, PS Burton. (1991). The influence of peptide structure on transport across Caco-2 cells. Pharm Res 8 1453-1460. 

Schafer, L., C. Van Alsenoy, and J. N. Scarsdale. 1982. Ab Initio Studies of Structural Features Not Easily Amenable to Experiment. 23. Molecular Structures and Conformational Analysis of the Dipeptide N-acetyl-N -methyl Glycyl Amide and the Significance of Local Geometries for Peptide Structures. J. Chem. Phys. 76, 1439-1444. 

Werner, U., T. Kissel, and W. Stuber. Effects of peptide structure on transport properties of seven thyrotropin releasing hormone (TRH) analogues in a human intestinal cell line (Caco-2), Pharm. Res. 1997, 14, 246-250... 

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