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Peptide deformylase Structure

PROTEIN STRUCTURE OF PEPTIDE DEFORMYLASES Three-dimensional Structure Metal-binding Site... [Pg.109]

This article summarises the general characteristics of a novel antibacterial target, peptide deformylase (PDF) and reviews the design, structure-activity relationships (SAR) and properties of known PDF inhibitors, including pre-clinical and clinical data for the most advanced members of this class. [Pg.110]

Methyl- l-[methyl-(2-pyridin-2-yl-ethyl)amino]propane-2-thiol (108) is a tridentate N2S ligand with an aliphatic thiolate ligand. The single-crystal X-ray structures demonstrate that the zinc complexes are close structural analogs of the His2Cys site found in peptide deformylase.873... [Pg.1225]

Tab. 19.2 Chemical structures of needle molecules as found in the project on peptide deformylase. The Kd values were determined by NMR titrations [17]... Tab. 19.2 Chemical structures of needle molecules as found in the project on peptide deformylase. The Kd values were determined by NMR titrations [17]...
See other pages where Peptide deformylase Structure is mentioned: [Pg.113]    [Pg.51]    [Pg.249]    [Pg.196]    [Pg.427]    [Pg.118]    [Pg.247]    [Pg.272]    [Pg.126]    [Pg.127]    [Pg.548]    [Pg.204]    [Pg.414]    [Pg.19]   
See also in sourсe #XX -- [ Pg.113 ]



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