Calcitonin gene-related peptide structure

Cooper, G.J.S. (1994) Amylin compared with calcitonin gene-related peptide Structure, biology, and relevance to metabolic disease. Endocr. Rev.. 1. 163 201. Wimalawansa, S.J. (1997) Amylin. calcitonin gene-related peptide, calcitonin, and adrenomedullin a peptide superfamlly. Cr/r. Rev. Neurobiol., 11.167-239. Alexander. S.P.H. et al. (1998) Receptors and ion channel nomenclature supplement. Ninth Edition. Trends Pharmacol. Sc/.. Suppl.. 19.1-98. 

Cooper GJ. Amylin compared with calcitonin gene-related peptide structure, biology, and relevance to metabolic disease. Endocr Rev 1994 15 163-201. 

Merck and Co., Inc., have patented imidazo[4,5-3]pyridines of the general structure 194, which have been found to be antagonists of calcitonin gene-related peptide (CGRP) receptors, which are useful for the treatment of the symptoms for headache, migraine, and cluster headaches <2005W0013894>. Merck have also patented the... 

Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides, which also includes calcitonin, adrenomedullin, and amylin. CGRP consists of 37 amino acids and displays approximately 30% structural homology with salmon calcitonin. 

Dennies, T.B., Fournier, A., St. Pierre, S., Quirion, R Structure activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity, J. Pharmacol. Exp. Ther. 1989, 251, 718-725. 

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