Peptide application

Zhao, Q., Sannier, F., Garreau, I., Lecoeur, C., and Piot, J. M., Reversed-phase high-performance liquid chromatography coupled with second-order derivative spectroscopy for the quantitation of aromatic amino acids in peptides application to hemorphins, /. Chromatogr. A, 723, 35, 1996. 

Feng, L Orlando, R. and Prestegard, J. H. (2006) Amide proton back-exchange in deuterated peptides applications to MS and NMR analyses. Anal. Chem. 78, 6885-6892. 

Galonic DP, Ide ND, van der Donk WA, Gin DY. Aziridine-2-carboxylic acid-containing peptides application to solution- and solid-phase convergent site-selective peptide modification. J. Am. Chem. Soc. 2005 127 7359-7369. 

R. Rosenfeld, Q. Zheng, S. Vajda, C. DeLisi, Computing the structure of bound peptides Application to antigen recognition by class I MHCs, J. Mol. Biol. 234 (1993), 515. 

Many important developments have been made during the last few years but are not yet commercially available. Specifically, there is an active interest in electrospray and continuous flow fast atom bombardment (FAB) for peptides. Applications using supercritical fluid chromatography (SFC) in combination with MB1 and DLI have been slow but continue to attract interest. The current work in capillary zone electrophoresis (with... 

A Somogyi, VH Wysocki, I Mayer. The effect of protonation site on bond stmgths in simple peptides Application of ab initio and modified neglect of differential over-... 

Results from testing combinatorial libraries will support the design of cocktails of peptides applicable in prophylactic or therapeutic tumor vaccination or the construction of immunomodulating peptides for therapy of autoimmune diseases. Peptide libraries are also one of the most promising tools in the development of therapeutic approaches based on the actual status of an individuals immune response. 

Hook DF, Bindschadler P, Mahajan YR et al (2005) The proteolytic stability of designed P-peptides containing a-peptide-bond mimics and of mixed a, P-peptides application to the construction of MHC-binding peptides. Chem Biodivers 2(5) 591-632... 

By varying the degree of cross-linking, gel filtration media can be manufactured that will separate different ranges of molecular sizes. Se-phadex G-10, G-15, and G-25 from Pharmacia and Biogel P-2 and P-4 from BioRad are commonly used for peptide applications as these gels fractionate low-molecular-weight compounds. 

Owing to their overall importance, the parenteral application route and the three application routes that are currently of strong academic interest (enteral, especially oral), increasing clinical relevance (pulmonary), or therapeutic potential (nasal) are described in more detail in the subsequent paragraphs. Further, noninva-sive routes of protein and peptide application like, for example, buccal [5], transder-mal [6], colonic [7], and rectal [8] application will not be discussed within this chapter because of their lower significance versus the aforementioned ones, as of today. 

Owing to the benefits mentioned above, the nasal route of peptide application already plays a significant role in the clinical practice of today. Depending on the outcome of the development activities... 

Conjugation of l,4,7,10-tetraazacyclododecane-l,4,7,10-tetraacetic acid (DOTA) and its derivatives to peptides, applications and future prospects of the conjugates 07MRO281. 

Shen, M. Guo, L. Wallace, A. Fitzner, J. Eisenman, J. Jacobson E. Johnson, R.S. Isolation and isotope labeling of cysteine- and methionine-containing tryptic peptides application to the study of cell surface proteolysis. Mol. Cell. Proteomics 2003, 2, 315-324. 

C.R. Daas, P.F.M. Choong, Biophysical delivery of peptides applicability for cancer therapy. Peptides 27, 3479-3488 (2006)... 

Chicz, R.M. and Urban, R.G. (1994). Analysis of MHC presented peptides applications in autoimmunity and vaccine development. Immunology Today, 15, 155-160 good review on a complicated subject. 

Owusu-Apenten, R., 2010. Bioactive Peptides Applications for Improving Nutrition and Health. CRC Press. 

Despite the occasional advantage of nonideal column behavior for specific peptide applications, such nonspecific interactions must be suppressed if ideal peptide/protein elution behavior is required, i.e., predictable elution times based on solute size only. The ability to predict the position and/or elution order of peptides during SEC of a peptide mixture would greatly simplify preliminary separation of peptides of interest from a chemical or proteolytic protein digest. Under conditions of ideal SEC, large peptide fragments can be quickly identified and removed. Thus, it is important to achieve a linear relationship between In... 

Bonnet D, OUivier N, Gras-Masse H et al (2001) Chemoselective acylation of fully de nt)tected hydrazine acetyl peptides. Application to the synthesis of lipopeptides. J Org Chem 66 443-446... 

An important analytical application of enzymatic microreactors is their use in biocatalysis, in order to transform a difficult-to-measure analyte into an easily measurable form. This could be represented by microreactors designed for digestion of proteins to convert them to more readily measured peptides. Applications of microreactors in continuous-flow chemistry have expanded rapidly over the past two decades, with numerous reports of higher conversions and yields compared to conventional batch equipment. In this chapter, a comprehensive discussion on the most recent trends in the development of enzymatic microreactors and their current applications are covered. 

Poly(elastin), another poly(peptide), is also being examined in both the medical and controlled release areas.20-32 Although this material is relatively new, and of synthetic origin, it could probably find utility in cosmetics. Other important poly(peptide) applications include their use as drug carriers,23 and biodegradable drug delivery systems.24... 

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