Peptide passive application

These intervention strategies can be considered as passive immunotherapy it may, however, be possible to actively immunize atopic individuals since there is evidence that neonatal or adult immunization with IgE can stimulate the formation of therapeutically useful anti-IgE auto-antibodies in animal systems (342). Their action suggests that the identification of structural determinants in IgE, which participate directly in IgE-receptor interaction, may form the basis for the development of peptide immunogens to induce the formation of antibodies, which can bind specifically to the receptor-binding sites of IgE in the circulation and to membrane IgE on B cells. Used as vaccines, such peptides could have a direct application in the treatment of all IgE-mediated allergies. 

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