Applications peptide-based

Recently, unique vesicle-forming (spherical bUayers that offer a hydrophilic reservoir, suitable for incorporation of water-soluble molecules, as well as hydrophobic wall that protects the loaded molecules from the external solution) setf-assembUng peptide-based amphiphilic block copolymers that mimic biological membranes have attracted great interest as polymersomes or functional polymersomes due to their new and promising applications in dmg delivery and artificial cells [ 122]. However, in all the cases the block copolymers formed are chemically dispersed and are often contaminated with homopolymer. 

To be successful in these applications, it is important that materials can self-assemble into precisely defined structures. Peptide-based polymers have many advantages over conventional synthetic polymers since they are able to hierarchically assemble into stable, ordered conformations [4]. Depending on the substituents of the amino acid side chain, polypeptides are able to adopt a multitude of... 

Yan CQ, Pochan DJ (2010) Rheological properties of peptide-based hydrogels for biomedical and other applications. Chem Soc Rev 39 3528-3540... 

Guo, X. and Matsui, H. (2005) Peptide-based nanotubes and their applications in bionanotechnology. Advanced Materials, 17 (17), 2037-2050. 

DTPA has also been used in the peptide-based " in-DTPA-octreotide. Octreotide is a shortened peptide analog of somatostatin designed to be more stable in vivo. Radiolabeling of octreotide for diagnostic imaging applications with radioisotopes for PET or SPECT has been investigated,... 

Sharma, V., Wang, Q. and Lawrence, D. S. (2008). Peptide-based fluorescent sensors of protein kinase activity Design and applications. Biochim Biophys. Acta. 1784, 94—99. 

R. J. Pieters, D. T. S. Rijkers, and R. M. J. Liskamp, Application of the 1,3-dipolar cycloaddition reaction in chemical biology Approaches toward multivalent carbohydrates and peptides and peptide-based polymers, QSAR Comb. Sci., 26 (2007) 1181-1190. 

Simple acyclic a,/ -unsaturated esters are not reactive in the conjugate addition of dialkylzincs. In contrast, nitro-substituted unsaturated esters68 and malonates69 are applicable for this reaction. Using peptide-based chiral phosphine 66, Hird and Hoveyda realized the Cu-catalyzed conjugate addition of Et2Zn to iV-acyloxazolidinones with excellent enantioselectivity (Scheme 21).70... 

Examples of NMR Applications in Peptide-Based Drug Design... 

Array-Based Techniques for Glycans Development and Applications Peptide Combinatorial Libraries Transcript Profiling Receptor-Ligand Interactions... 

Figure 17.3 Application of precursor-ion analysis MS-MS analysis mode to screening for peptides in complex mixtures. (A) Spectrum of a synthetic peptide, hidden in the noise, (B) precursor-ion MS-MS spectrum using the Leu/lle-immonium ion at m/z 86 as common product ion to detect the peptide, (C) production MS-MS spectmm of the synthetic peptide based on the [M-i-3H] -ion. Reprinted from [144] with permission. 1996. American Chemical Society.

Linkhart SG, Linkhart TA, Taylor AK, Wergedal JE, Bettica P, Baylink DJ. Synthetic peptide-based immunoassay for amino-terminal propeptide of type I procoBagen application for evaluation of bone formation. Clin Chem 1993 39 2254-8. 

Synthetic peptide-based polymers are not new materials homopolymers of polypeptides have been available for many decades and have only seen hmited use as structural materials [5,6]. However, new methods in chemical synthesis have made possible the preparation of increasingly complex polypeptide sequences of controlled molecular weight that display properties far superior to ill-defined homopolypeptides [7]. Furthermore, hybrid copolymers, that combine polypeptide and conventional synthetic polymers, have been prepared and combine the functionality and structure of peptides with the processabihty and economy of polymers [8,9]. These polymers are well suited for applications where polymer assembly and functional domains need to be at length scales ranging from nanometers to microns. These block copolymers are homogeneous on a macroscopic scale, but dissimilarity between the block segments typically results in microphase heterogeneity yield-... 

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