Pentyl Hydrochlorid

Figure 5. Survival effects for CM-chitin-5FU conjugate(7) and the hydrochloride salt of 4-[(amino-n-pentyl)ester]methylene-5FU(14) against p3 8 leukemia in mice ip/ip. 7(DCM Omol fc D5FU=35mol%),...

Auf ahnliche Weise erhalt man 3-(5-Carboxy-pentyl)-sydtion-min-Hydrochlorid< 9. 

Acetic acid 4-dimethylamino-1 -ethyl-2,2-diphenyl-pentyl ester, [S-(R R )]-p-[2-(Dimethyl-amino)propyl]-a-ethyl-p-phenylbenzeneethanol acetate, C23H31N02, Mr 353.50 hydrochloride C23H31N02. HCI, Mr 389.96, mp 215 °C, [a]D25 -60° (c = 0.2, water)... 

TERMINALIA ARJUNA, BARK EXTRACT 5H-TETRAZOLOAZEPINE, 6.7.8.9-TETRAHYDRO-THEOPHYLLINE, 8-PENTYL-THEOPHYLLINE, 7 (1,3 DIOXOLAN-2-YLMETHYL) -THEOPHYLLINE, 8-BUTYL-, HYDROCHLORIDE... 

A mixture of 4-[4-(diphenylmethyl)-l-piperazinylmethyl]-Nl-ethyl-l,2-benzenediamine and acetic acid is stirred at room temperature till all solid enters solution. Then there are added pentyl ethanimidate hydrochloride and stirring is continued first for 1 h at room temperature and further for 1 h at reflux. The reaction mixture is evaporated and the residue is stirred in water. The whole is alkalized with a sodium hydroxide solution and the product is extracted with dichloromethane. The extract is dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and methanol as eluent. The pure fractions are collected and the eluent is evaporated. The product is filtered off and dried, yielding 5-[4-(diphenylmethyl)-l-piperazinylmethyl]-l-ethyl-2-butyl-lH-benzimidazole melting point 124.8°C (crystallized from 4-methyl-2-pentanone). 

METHYL PENTYL KETONE see MGN500 METHYL-N-PENTYLNITROSAMINE see AOLOOO METHYLPERONE HYDROCHLORIDE see FKIOOO ( )-a-METHYLPHENETHYLAMINE see BBKOOO dl-Ot-iMETHYLPHENETHYLAAENE see BBKOOO a-METHYLPHENETHYK-lMINE, d-FORM see AOA500 d-a-METHYLPHENETHYLAMINE SULFATE see BBK500... 

The stability, both chemical and physical, of a drug may be enhanced or retarded by salt formation. For example, solid dosage forms of diclofenac contain salt forms rather than the less stable free acid. Although salt formation may result in improved dissolution rate and bioavailability of a poorly water-soluble compound, the preparation of stable salt forms for some drugs may not be feasible and the free acid or base forms may be preferred. For example, the base form of a-pentyl-3-(2-quinolinylmethoxy)benzenemethanol was selected for dosage form design because of the physical instability of its hydrochloride salt. ... 

One other cannabinoid receptor agonist of note is 3-(5 -cyano-l, l -dimclhyl-pentyl)-l-(4-N-morpholinobutyryloxy)-A -THC hydrochloride (0-1057). Thus, unlike all established cannabinoid receptor agonists, this is readily soluble in water and yet, compared to CP55940, its potency in the cyclic AMP assay is just... 

For some drugs, preparation of stable salts may not be feasible, or free acid or free base forms may be preferred. A reported example compares the free base and hydrochloride salt of the poorly water-soluble drug, a-pentyl-3-(2-quino-linylmethoxy)benzenemethanol, known as REV 5901 (Fig. 8) (11). For this drug substance, lower solubility of the chloride salt, along with equivalent dissolution rates, resulted in the free base being chosen for development. 

An aq. soln. of 6-amino-7-octanone-l-carboxylic acid hydrochloride mixed with NH4-thiocyanate, evaporated to dryness on a steam bath during K hrs., the product evaporated twice with water, HC1 added, and allowed to stand 24 hrs. —l-methyl-5- (fo-carboxy-n-pentyl)-imidazole-2-thione. Y 69%. (F. e. with lower yields s. G. Swain, Soc. 1948, 1552.)... 

Oximes of sterically hindered ketones can be obtained, in very slow reactions but often in quantitative yield, by treatment with hydroxylamine hydrochloride in the presence of an excess of potassium tert-pentyl oxide at room temperature.950... 

Trimethylacetophenone oxime 950 Hydroxylamine hydrochloride (5.5 g) and 2,4,6-trimethylacetophenone (10 g) are added to a solution (125 ml) of potassium tert-pentyl oxide (prepared from 98 g of potassium in 1250 ml of anhydrous tert-pentyl alcohol), and the mixture is kept for 32 days in a closed vessel. The pentyl alcohol is then removed in a rotary evaporator and the residue is shaken with a solution of ammonium chloride (5.3 g) in water (100 ml). If the oxime is precipitated as an oil, more water must be added. The yield is 10.8 g, 98 %, of a product melting at 98-101° after sublimation the m.p. is 101.5-102.5°. 

The amine hydrochloride is dissolved or suspended in a three-fold amount of glacial acetic acid and treated at 10° with the calculated amount of pentyl nitrite, with stirring when all is dissolved, the mixture is treated cautiously with ether, which precipitates the diazonium salt. 

Thebaine-maleimide adducts have been prepared, and the Diels-Alder reaction of thebaine with cyclic azo-dienophiles has been investigated. " Nitrosation of thebaine hydrochloride with nitrosyl chloride or pentyl nitrite in methanol or ethanol gives 7-hydroxyiminoneopinone dimethyl or diethyl acetal. " The chemistry of 14-bromocodeinone and its dimethyl acetal has been studied in some detail, including catalytic hydrogenation, "" methanoly-sis, " debromination, "" dehydrobromination, " and solvolysis.Efforts are continuing in the preparation of novel analgesics in the morphine-thebaine series. 

The following sequence (equation 6) constitutes a convenient alternative to the conversion of alkyl halides into alkylamines by the Gabriel reaction with potassium phthaUmide. In this one-pot procedure, an alkyl bromide RBr (R = Bu, -Bu, 2-pentyl, 2-octyl, PhCH2CH2, HC=C, PhCH=CHCH2, cyclopentyl, cyclohexyl etc.) is treated with sodium azide in benzene in the presence of tetrabutylammonium bromide under phase-transfer conditions. Triethyl phosphite is then added and the resulting iminophosphorane is decomposed to the alkyl amine hydrochloride by adding benzene and hydrogen chloride. ... 

Among them, the chiral Schiff bases (85), rigidified at the lower rim by a tartaric acid bridge, show a weak preference in general (TTd/TTl = 1.06-1.95, when X = Phe, Cy) for D-amino acids methyl ester hydrochloride (d-AA-OCH3 HCI) over the L-isomers, but the receptor derived from (R)-2-heptylamine (85, X = pentyl) has a remarkable... 

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