Dosage form design

The rationale of the dosage form design (e.g., if a drug is rapidly destroyed in solution at a pH of 2 or below, the design of an oral product must enable the drug to get through the stomach without substantial dissolution)... 

As discussed previously, drug absorption may be impaired or improved when food is present in the GIT. Food may reduce the rate or extent of absorption by virtue of reduced gastric-emptying rate, which is particularly important for compounds unstable in gastric fluids and for dosage forms designed to release drug... 

WJ Westlake. The design and analysis of comparative blood-level trails In J Swarbrick, ed. Current Concepts in the Pharmaceutical Sciences Dosage Form Design and Bioavailability. Philadelphia, PA Lea Febiger, 1973. 

M. Rowland, Effect of some physiologic factors on bioavailability of oral dosage forms, in Dosage Form Design and Bioavailability (J. Swarbrick, Ed.), Lea Febiger, Philadelphia, 1973, pp. 181-222. 

FS Horn, JJ Miskel. Enhanced drug dissolution rates for a series of drugs as a function of dosage form design. Lex Sci 8(1) 18-26, 1971. 

A. Biological Factors Influencing Oral Sustained-Release Dosage Form Design... 

Mass transfer phenomena exist everywhere in nature and are important in the pharmaceutical sciences. We may think of drug synthesis preformulation studies dosage form design and manufacture and drug absorption, distribution, metabolism, and excretion. Mass transfer plays a significant role in each. Mass transfer is referred to as the movement of molecules caused not only by diffusion but also by convection [1],... 

Ashford M (2002) Bioavailability—Physiochemical and Dosage Form Factors In Pharmaceutics the Science of Dosage Form Design. In M Aulton (Ed.), Pharmaceutics. The Science of Dosage Form Design. 2nd Ed. Churchill Livingstone, pp 234-252. 

The dosage-form design is guided by the properties of the drug candidate. If an NCE does not have suitable physical and chemical properties or pharmacokinetic attributes, the development of a dosage form (product) may be difficult and may sometimes be even impossible. Any heroic measures to resolve issues related to physicochemical and biopharmaceutical properties of drug candidates add to the time and cost of drug... 

Serajuddin, A.T.M., Sheen, P.C., Mufson, D., Bernstein, D.F., and Augustine, M.A., Preformulation study of a poorly water soluble drug, alpha-pentyl-3-(2-quinolinyl-methoxy) benzenemethanol selection of the base for dosage form design, /. Pharm. Sci., 75, 492, 1986. 

With dosage form design, it is often necessary to compare the performance of two different granule formulations. These two formulations differ in composition and, as a consequence, vary also in the amount of granulating liquid required. 

ROBUST FORMULATIONS AND DOSAGE FORM DESIGN The Effect of Percolation Theory... 

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