Chiba University

Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan. 

Culture Collection of Pathogenic Fungi and Actinomycetes (Chiba University Research Center for Pathogenic Fungi and Microbial Toxicoses). 

Department of Chemistry, Faculty of Science, Chiba University, Yayoi-cho, Inage-ku Chiba 263-8522, Japan, Phone Fax 81—43-290-2791, e-mail imamoto scichem.s. chiba-u.ac.jp... 

AT T Bell Laboratories, 1,38,157,188,209,251 Chiba University, 421 Cornell University, 73,99,233 Hewlett Packard Laboratories, 329 Hitachi Ltd., 316 IBM Almaden Research Center, 26,56,73,99,114,382 Kanagawa University, 99 Kyoto Institute of Technology, 397 Matsushita Electric Industrial Company Ltd., 266... 

Laboratory of Physical Chemistry, Chiba University, 1-33, Yayoi, Chiba (280) Japan... 

Chiba University, Faculty of Engineering, Chiba, Japan 260... 

For 3-deoxyanthocyanin biosynthesis the 3-hydroxyl is, of course, lacking from the ANS substrates (e.g., apiforol). Whether a specific ANS is thus involved in 3-deoxyanthocyanin biosynthesis is not clear. However, it has been postulated that the reaction may still proceed through 3-hydroxylation, and initial results suggest recombinant ANS from species that do not produce 3-deoxyanthocyanins may still use apiforol as a substrate to produce apigenini-din (results of J-I. Nakajima and K. Saito of Chiba University, Japan, with the authors coworkers in New Zealand). 

One of the most powerful strategies for asymmetric ring construction is to desymmelrize a preformed ring. Yasamusa Hamada of Chiba University in Japan has reported (J. Am. Chem. Soc. 2004, /26, 3690) that the inexpensive diaminophosphine oxide 2 nicely catalyzes the asymmetric alkylation of the cyclohexanone carboxylate 1 to give 3. Although no examples were given, this asymmetric alkylation would probably work as well with heterocyclic P-ketoesters. 

We are grateful to Professor Yamazaki at Chiba University for furnishing a sample of natural paraherquamide A. 

Physical Chemistry, Material Science, Graduate School of Natural Science and Technology, Chiba University, Inage, Yayoi,m Chiba 263 -8522, Japan... 

Department of Materials Technology Faculty of Engineering, Chiba University... 

Akira Yanagisawa Department of Chemistry Faculty of Science Chiba University Inage... 

I thank Prof. T. Imamoto at Chiba University for his valuable information. 

TETSUO SATOH, PhD, FATS Professor Emeritus, Chiba University, Director, HAB Research Instimte, Cornea Center, Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa 272-8513, Chiba, Japan... 

Department of Materials Science, Faculty of Engineering, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263, Japan... 

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