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Pas - Aminosalicylic acid

PABA, /7-aminobenzoic acid PAS, / -aminosalicylic acid PA, procainamide SMZ, sulphamethazine. Data from Weber (1987) The Acetylator Genes and Drug Response (New York Oxford University Press). [Pg.267]

Substitution of an amino group into the molecule affords an iigent with antibacterial activity. Although seldom used alone, l, ira- aminosalicylic acid (PAS, 7) has been employed as an adjunct Id streptomycin and isoniazid in treatment of tuberculosis. [Pg.109]

The three standard drugs used in the treatment of tuberculosis were streptomycin (considered above), -aminosalicylic acid (PAS) and isoniazid (isonicotinylhydrazide, INH synonym, isonicotinic acid hydrazine, INAH). The tubercle bacillus rapidly becomes resistant to streptomycin, and the role of PAS was mainly that of preventing this development of resistance. The current approach is to treat tuberculosis in two phases an initial phase where a combination of three dmgs is used to reduce the bacterial level as rapidly as possible, and a continuation phase in which a combination of... [Pg.117]

Fig. 20 Mean plasma concentrations of unchanged drug from 12 subjects following administration of four different preparations of p-aminosalicylic acid (PAS). Data were corrected to 70 kg of body weight and to a dose equivalent of 4 g of free acid. (From Ref. 24.). Fig. 20 Mean plasma concentrations of unchanged drug from 12 subjects following administration of four different preparations of p-aminosalicylic acid (PAS). Data were corrected to 70 kg of body weight and to a dose equivalent of 4 g of free acid. (From Ref. 24.).
Para-aminosalicylic Acid (PAS), like the sulfonamides (see Chapter 44), is a structural analogue of p-aminobenzoic acid (PABA). It is a folate synthesis antagonist that interferes with the incorporation of PABA into folic acid. PAS is bacteriostatic, and in vitro, most strains of M. tuberculosis are sensitive to a concentra-... [Pg.560]

P aeruginosa—Pseudomonas aeruginosa P carinii—Pneumocystis carinii P kellicotti—Paragonimus kellicotti P mirabilis—Proteus mirabilis P vivax—Plasmodium vivax PABA— p-aminobenzoic acid PAS—para-aminosalicylic acid Pb—lead... [Pg.278]

Aminosalicylic acid derivatives para-aminosalicylate sodium (PAS sodium)... [Pg.616]

Abbreviations-. PA BA, p-aminobenzoic acid PAS, p-aminosalicylic acid PA, procainamide SMZ, sulfamethazine. [Pg.154]

Aminosalicylic acid (Paser, PAS) exerts its effects in a manner similar to the sulfonamide drugs that is, aminosalicylic acid is structurally similar to para-aminobenzoic acid (PABA) and inhibits folic acid synthesis by competing with PABA in tuberculosis... [Pg.510]

Oguchi and coworkers examined the decarboxylation behavior of -aminosalicylic acid (PAS) as a freeze-dried solid under thermal stress conditions (80°C) in the presence of the excipients pullulan (a linear polysaccharide which can not form inclusion complexes with PAS) and a-cyclodextrin (39). The solid-state stability was shown to correlate with the fraction of amorphous PAS. Increasing relative amounts of pullulan resulted in higher fractions of amorphous PAS. Rapid freezing (liquid nitrogen) was shown to result in a greater relative amount of amorphous drug, as expected. [Pg.287]

Commonly used drugs (other than isoniazid) affected by NAT2 polymorphism were procainamide, hydralazine, dapsone, and sulfonamides with an increase of side effects in all cases. A selective substrate of NATl is -aminosalicylic acid (PAS), but its genetic variation was never clinically important (52). Because of such lack of importance, more attention is often paid to the fact that various industrial chemicals with carcinogenic potential, and mutagenic heterocyclic amines, are substrates of both N-acetyltransferases (53). The presence or absence of these transferases will determine some incidences of cancer (54). Attempts have been made to ascribe cancer incidences in different populations to acetyltransferase differences (55). [Pg.231]

A series of compounds containing the same chelating moiety, namely 4-aminosalicylic acid, with different alkyl chains, was synthesized. The structure of the ligands (PAS-C ) is the following ... [Pg.153]

Synonyms. Aminosalylum Para-aminosalicylic Acid PAS Pasalicylum. [Pg.343]


See other pages where Pas - Aminosalicylic acid is mentioned: [Pg.1679]    [Pg.1728]    [Pg.1728]    [Pg.1743]    [Pg.215]    [Pg.1679]    [Pg.1728]    [Pg.1728]    [Pg.1743]    [Pg.1679]    [Pg.1728]    [Pg.1728]    [Pg.1743]    [Pg.1679]    [Pg.1728]    [Pg.1728]    [Pg.1743]    [Pg.215]    [Pg.1679]    [Pg.1728]    [Pg.1728]    [Pg.1743]    [Pg.1679]    [Pg.1728]    [Pg.1728]    [Pg.1743]    [Pg.297]    [Pg.1114]    [Pg.114]    [Pg.287]    [Pg.53]    [Pg.105]    [Pg.565]    [Pg.367]    [Pg.1049]    [Pg.1049]    [Pg.6]    [Pg.418]    [Pg.166]    [Pg.1098]    [Pg.550]    [Pg.166]    [Pg.119]    [Pg.416]   


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