5-Aminosalicylates

SALICYLIC ACID AND RELATED COMPOUNDS] (Vol 21) p-aminosalicylic acid [65-49-6]... 

Aminosalicylic acid and its salts have been used in the treatment of tuberculosis, Aminosalicylic acid can be prepared by the carboxylation of m- am in oph en o1 (32). Aminosalicylic acid USP assays not less than 98.5% and not more than 100.5%, calculated on the anhydrous basis. The antitubercular agents are likely to be used as the more tolerated salts calcium [133-15-3] potassium [133-09-5] sodium [133-10-8] and the ethyl [6069-17-2] and phenyl [133-11-9] esters of -aminosalicylic acid. 

Aminosalicylic acid (5-amino-2-hydroxybenzoic acid) [89-57-6] M 153.1, m 276-280 , 283 (dec), pK 2.74 (CO2H), pK 5.84 (NH2). Cryst as needles from H2O containing a little NaHS03 to avoid aerial oxidation to the quinone-imine. The Me ester gives needles from C6H6, m 96°, and the hydrazide has m 180-182° (From H2O). [Fallab et al. Helv Chim Acta 34 26 1951, Shavel J Amer Pharm Assoc 42 402 1953.]... 

Sodium 4-aminosalicylate (2H2O) [6018-19-5] M 175.1. Crystd from water at room temperature (2mL7g) by adding acetone and cooling. 

Substitution of an amino group into the molecule affords an iigent with antibacterial activity. Although seldom used alone, l, ira- aminosalicylic acid (PAS, 7) has been employed as an adjunct Id streptomycin and isoniazid in treatment of tuberculosis. 

Paludrine 1, 115 Pamaquine 1, 345 Pamatolol T, 28 Pancuronium chloride 163 Papaverine 1, 347 Para-aminosalicylic acid J, ... 

The benzoic acid moiety common to many of the benzamides is prepared in straightforward manner from the methyl ether of p-aminosalicylic acid 141. Acylation on nitrogen (142) followed by chlorination gives intermediate 143 benzoic acid 144 is then obtained by removal of the acetyl group. Condensation of this acid with an aminopiperidine could be achieved by means of the mixed anhydride (prepared by reaction with ethyl chlonoformate), which affords clebopride (145). Reaction with 3-aminoquinuclidine (146) of the intermediate prepared from acid 144 with carbonyldiimidazole affords zacopride (147) [36]. 

As described in U.S. Patent 427,564, aminosalicylic acid may be prepared from m-amino-phenol by heating with ammonium carbonate in solution under pressure. 

Quingestanol acetate Stanzolol Tegafur Tiopronin Tocainide Vindesine Xipamid 2oxazo lamina Ammonium acetate Cyclopentamine HCl Ammonium carbonate Aminosalicylic acid Phenytoin... 

Tear-Efrin - Phenylephrine HCI Tebacin acid - Aminosalicylic acid Tebertin - Inosine Teberus Ethionamide Tebesium - Isoniazid Tebilon - Isoniazid Tebloc - Loperamide HCI Tebrezid - Pyrazinamide Techlon - Pentoxifylline Teclinazets - Tetracycline T-E Cypionate - Estradiol cypionate Tedarol - Triamcinolone Tedarol - Triamcinolone acetonide Tedarol - Triamcinolone diacetate Teejel - Choline salicylate Tefsiel - Tegafur... 

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