Para-aminosalicylic acid

Paludrine 1, 115 Pamaquine 1, 345 Pamatolol T, 28 Pancuronium chloride 163 Papaverine 1, 347 Para-aminosalicylic acid J, ... 

PAG , 111 Paludrine, 115 Pamaquine, 345 Papaverine, 347, 348 Para-aminobenzoic acid, in bacterial metabolism, 109, 121 Para-aminosalicylic acid, 109 Paraethoxycaine, 10, 11 Paramethadione, 232 Paramethasone, 200 Parasympathetic nervous system, 35, 62... 

Para-aminosalicylic Acid (PAS), like the sulfonamides (see Chapter 44), is a structural analogue of p-aminobenzoic acid (PABA). It is a folate synthesis antagonist that interferes with the incorporation of PABA into folic acid. PAS is bacteriostatic, and in vitro, most strains of M. tuberculosis are sensitive to a concentra-... 

P aeruginosa—Pseudomonas aeruginosa P carinii—Pneumocystis carinii P kellicotti—Paragonimus kellicotti P mirabilis—Proteus mirabilis P vivax—Plasmodium vivax PABA— p-aminobenzoic acid PAS—para-aminosalicylic acid Pb—lead... 

Synonyms. Aminosalylum Para-aminosalicylic Acid PAS Pasalicylum. 

Introdnced in 1961 for the treatment of tuberculosis, ethambutol supplanted para-aminosalicylic acid fiar the initial treatment and retreatment of tuberculosis. 

Methyidopa Antithyroid agents (e.g., propylthiouracil) para-aminosalicylic acid, captopril. 

The immunogenicity of sulfonamide antimicrobials may be due to the presence of an arylamine group at the N4 position of the sulfonamide molecule. Thus, allergic crossreactions between different sulfonamides can occur. Therefore, in cases of known hypersusceptibility to a specific sulfonamide exposure to other sulfonamides should be avoided. Cross-reactions can even occur with para-aminosalicylic acid and local anesthetics of the procaine type however, the real frequency of these cross-sensitivities is not known and their significance is undetermined. It should be noted that as many as 50% of... 

Sulfonamides were first reported as causative agents in users of sulfanilamide vaginal cream. para-Aminosalicylic acid frequently produced the syndrome in tuberculosis patients being treated with this agent. There have been nine reported cases associated with sulfasalazine use in inflammatory bowel disease. The drug as-... 

The substrates of acetylation, schematized in Fig. 13.25, are mainly amines of medium basicity. Very few basic amines (primary or secondary) of medicinal interest have been reported to form N-acetylated metabolites (reaction 1), and when they did, the yields were low. In contrast, a large variety of primary aromatic amines are N-acetylated (reaction 2). Thus, several dmgs such as sulfonamides and para-aminosalicylic acid (30) (PAS Fig. 13.26) are acetylated to large extents, not to mention various carcinogenic amines such as benzidine. 

Figure 13.26. para-Aminosalicylic acid (30), isoni-azid (31), and hydralazine (32). 

Kuo PT, Fan WC, Kostis JB, Hayase K. Combined para-aminosalicylic acid and dietary therapy in Icng-teim cCTitrol of hy percholesterolemia and hy pertriglyceridemia (tyfies II, and h>perlipq)Foteinemia) Circulaticm (1976) 53, 338-41... 

Boger WP, Pitts FW. Influence of p -(Di-n-pr ylsulfamyl)-benzoic acid, Benem id on para-aminosalicylic acid(PAS)plaanacaicenlialions../4mi 7 M6 rc(1950)61, 862-7. 

Hanngren A, Borga O, Sjoqvist F. Inactivation of isoniazid (INH) in Swedish tuberculous pa-tients befcxe and during treatment with para-aminosalicylic acid (PAS). Scand J Respir Dis (1970)51,61-9. 

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