Extractions, partition coefficient

The constant K is termed the distribution or partition coefficient. As a very rough approximation the distribution coefficient may be assumed equal to the ratio of the solubilities in the two solvents. Organic compounds are usually relatively more soluble in organic solvents than in water, hence they may be extracted from aqueous solutions. If electrolytes, e.g., sodium chloride, are added to the aqueous solution, the solubility of the organic substance is lowered, i.e., it will be salted out this will assist the extraction of the organic compound. 

Let us consider a specific example, viz., the extraction of a solution of 4 Og. of n-butyric acid in 100 ml. of water at 15° with 100 ml. of benzene at 15°. The partition coefficient of the acid between benzene and water may be taken as 3 (or J between water and benzene) at 15°. For a single extraction with benzene, we have ... 

Continuous Extractions An extraction is still feasible even when the component of interest has an unfavorable partition coefficient, provided that ah other components in the sample have significantly smaller partition coefficients. Because the partition... 

Earlier we learned that the partitioning of a solute between two phases is described by a partition coefficient. If the solute is initially in an aqueous phase and is extracted into an organic phase ... 

In the simplest form of liquid-liquid extraction, the only reaction affecting extraction efficiency, is the partitioning of the solute between the two phases (Figure 7.20). In this case the distribution ratio and the partition coefficient are equal. 

For a simple liquid-liquid extraction, the distribution ratio, D, and the partition coefficient, Kd, are identical. 

A weak acid, HA, with a fQ of I.O X 10, has a partition coefficient, Rp, between water and an organic solvent of I20( What restrictions on the sample s pH are necessary to ensure that a minimum of 99.9% of the weak acid is extracted in a single step from 50.0 mF of water using 50.0 mF of the organic solvent ... 

A sample contains a weak acid analyte, HA, and a weak acid interferent, HB. The acid dissociation constants and partition coefficients for the weak acids are as follows Ra.HA = 1.0 X 10 Ra HB = 1.0 X f0 , RpjHA D,HB 500. (a) Calculate the extraction efficiency for HA and HB when 50.0 mF of sampk buffered to a pH of 7.0, is extracted with 50.0 mF of the organic solvent, (b) Which phase is enriched in the analyte (c) What are the recoveries for the analyte and interferent in this phase (d) What is the separation factor (e) A quantitative analysis is conducted on the contents of the phase enriched in analyte. What is the expected relative erroi if the selectivity coefficient, Rha.hb> is 0.500 and the initial ratio ofHB/HA was lO.O ... 

Carbon tetrachloride extracts chlorine monoxide but not HOCl from concentrated HOCl solutions. For the equilibrium, Cl2 0(aq) Cl2 0(CCl4), the partition coefficient at 0°C is 2.22 (55,84). 

Extraction from Aqueous Solutions Critical Fluid Technologies, Inc. has developed a continuous countercurrent extraction process based on a 0.5-oy 10-m column to extract residual organic solvents such as trichloroethylene, methylene chloride, benzene, and chloroform from industrial wastewater streams. Typical solvents include supercritical CO9 and near-critical propane. The economics of these processes are largely driven by the hydrophihcity of the product, which has a large influence on the distribution coefficient. For example, at 16°C, the partition coefficient between liquid CO9 and water is 0.4 for methanol, 1.8 for /i-butanol, and 31 for /i-heptanol. 

Extraction for enzyme recovery is a common process. Polyethylene glycol-dextran mixture is used to recover a-amylase from fermentation broth. Given a partition coefficient of 4.2, calculate the maximum enzyme recovery when... 

The following physico-chemical properties of the analyte(s) are important in method development considerations vapor pressure, ultraviolet (UV) absorption spectrum, solubility in water and in solvents, dissociation constant(s), n-octanol/water partition coefficient, stability vs hydrolysis and possible thermal, photo- or chemical degradation. These valuable data enable the analytical chemist to develop the most promising analytical approach, drawing from the literature and from his or her experience with related analytical problems, as exemplified below. Gas chromatography (GC) methods, for example, require a measurable vapor pressure and a certain thermal stability as the analytes move as vaporized molecules within the mobile phase. On the other hand, compounds that have a high vapor pressure will require careful extract concentration by evaporation of volatile solvents. 

Water solubility, dissociation constant(s) and n-octanol/water partition coefficients allow one to predict how an analyte may behave on normal-phase (NP), reversed-phase (RP), or ion-exchange solid-phase extraction (SPE) for sample enrichment and cleanup. 

The pH-metric technique used to determine partition coefficients was first used in the 1950s in solvent extraction of metal complexes [280-282], but it is in pharmaceutical research that it is most widely used thanks to the recent development of a fully automated and computer-controlled apparatus [125,283]. The potentiometric approach has been validated in various solvent systems [284-287], and it has become a relevant and expanding experimental technique to obtain lipophilicity descriptors [257,287-289]. 

One possibility for increasing the minimum porosity needed to generate disequilibria involves control of element extraction by solid-state diffusion (diffusion control models). If solid diffusion slows the rate that an incompatible element is transported to the melt-mineral interface, then the element will behave as if it has a higher partition coefficient than its equilibrium partition coefficient. This in turn would allow higher melt porosities to achieve the same amount of disequilibria as in pure equilibrium models. Iwamori (1992, 1993) presented a model of this process applicable to all elements that suggested that diffusion control would be important for all elements having diffusivities less than... 

At each step, a fraction of fluid f is added to the mantle wedge from the slab. The bulk partition coefficients used for fluid dehydration can be derived from published mineral/fluid partition coefficients (see Tables Al and A2). The composition of the residual slab is estimated as follows after At which is the time step between two melt extractions (similar equation for Th and Pa) ... 

MHE can be used for substances of high volatility with a small partition coefficient. Method is based on a stepwise gas extraction at equal time intervals. Normal headspace chromatogram is run, a fraction of the gas phase exhausted, and a second headspace chromatogram is run. -The difference in petUc areas provides a measure of the total peak area of the analyte. 

Essentially, extraction of an analyte from one phase into a second phase is dependent upon two main factors solubility and equilibrium. The principle by which solvent extraction is successful is that like dissolves like . To identify which solvent performs best in which system, a number of chemical properties must be considered to determine the efficiency and success of an extraction [77]. Separation of a solute from solid, liquid or gaseous sample by using a suitable solvent is reliant upon the relationship described by Nemst s distribution or partition law. The traditional distribution or partition coefficient is defined as Kn = Cs/C, where Cs is the concentration of the solute in the solid and Ci is the species concentration in the liquid. A small Kd value stands for a more powerful solvent which is more likely to accumulate the target analyte. The shape of the partition isotherm can be used to deduce the behaviour of the solute in the extracting solvent. In theory, partitioning of the analyte between polymer and solvent prevents complete extraction. However, as the quantity of extracting solvent is much larger than that of the polymeric material, and the partition coefficients usually favour the solvent, in practice at equilibrium very low levels in the polymer will result. 

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