Particle size testing distribution

Mill type What mill type (e.g., impact or screen) should be used Each has several variants, depending on the means to reduce the particles. The type of mill can generate a different particle size/size distribution. Particle size testing will need to be conducted and the results examined when substituting mill types. 

The performance of pMDIs and DPIs is scrutinized in terms of efficiency and reproducibility of dose delivery, particle size, and distribution under a range of storage conditions, with respect to temperature and humidity, for extended periods of time (up to 2 years).50 Since nebulizer products do not bring the device in contact with the drug until the point of use, a slightly different approach is taken to their approval. Recommended devices and conditions of operation for the delivery of a particular drug must now be stated. The solution formulation is then viewed as a sterile parenteral product and requires concomitant testing. 

The difference in color of the catalysts, even though the gold particle size and distribution was similar, can be explained by a different interaction between the gold particles and the supports. The most relevant results of the catalyst characterization are provided in Table 12.1. The results of the catalytic tests are summarized in Table 12.2. 

Most tests of the validity of the BET area have been carried out with finely divided solids, where independent evaluation of the surface area can be made from optical microscopic or, more often, electron microscopic observations of particle size, provided the size distribution is fairly narrow. As already explained (Section 1.10) the specific surface obtained in this way is related to the mean projected diameter through the equation... 

Screening. A 100-g sample of mica is usually used for this test, plus a rack of six Tyler sieves and a pan. The stack of sieves containing the sample is rotated, and after screening, the mica remaining on each screen is weighed and the percentage retained is calculated. A combination of wet and dry screening may also be used to determine particle size distribution of fine mica (<0.147 mm ( — 100 mesh)). 

Several properties of the filler are important to the compounder (279). Properties that are frequentiy reported by fumed sihca manufacturers include the acidity of the filler, nitrogen adsorption, oil absorption, and particle size distribution (280,281). The adsorption techniques provide a measure of the surface area of the filler, whereas oil absorption is an indication of the stmcture of the filler (282). Measurement of the sdanol concentration is critical, and some techniques that are commonly used in the industry to estimate this parameter are the methyl red absorption and methanol wettabihty (273,274,277) tests. Other techniques include various spectroscopies, such as diffuse reflectance infrared spectroscopy (drift), inverse gas chromatography (igc), photoacoustic ir, nmr, Raman, and surface forces apparatus (277,283—290). 

The summation term is the mass broken into size interval / from all size intervals between j and /, and S is the mass broken from size internal i. Thus for a given feed material the product size distribution after a given time in a mill may be deterrnined. In practice however, both S and b are dependent on particle size, material, and the machine utilized. It is also expected that specific rate of breakage should decrease with decreasing particle size, and this is found to be tme. Such an approach has been shown to give reasonably accurate predictions when all conditions are known however, in practical appHcations severe limitations are met owing to inadequate data and scale-up uncertainties. Hence it is stiH the usual practice to carry out tests on equipment to be sure of predictions. 

In order to define the extent of emissions from automotive brakes and clutches, a study was carried out in which specially designed wear debris collectors were built for the dmm brake, the disk brake, and the clutch of a popular U.S. vehicle (1). The vehicle was driven through various test cycles to determine the extent and type of brake emissions generated under all driving conditions. Typical original equipment and aftermarket friction materials were evaluated. Brake relines were made to simulate consumer practices. The wear debris was analyzed by a combination of optical and electron microscopy to ascertain the asbestos content and its particle size distribution. It was found that more than 99.7% of the asbestos was converted to a nonfibrous form and... 

Testing. The Technical Association of the Pulp and Paper Industry (TAPPl) gives test methods that are widely used by kaolin suppHers to the paper iadustry. These iaclude tests for viscosity, viscosity stabiUty, brightness, pH, particle size distribution, moisture content, and screen residue (12). 

Testing. Various test methods are provided by ASTM (16). These iaclude pigment tests of importance such as chemical analysis, presence of oversize particles, oil absorption, particle size distribution, degree of dispersion, presence of soluble components, etc. Numerous tests are also given by ASTM for the properties of filled and unfilled polymers. These iaclude, for example, such properties as impact resistance, stiffness, viscosity, tear resistance, hardness, color, and electrical resistivity. 

Mechanical Properties. Mechanical properties (4,6,55) are important for a number of steps in coal preparation from mining through handling, cmshing, and grinding. The properties include elasticity and strength as measured by standard laboratory tests and empirical tests for grindabiUty and friabihty, and indirect measurements based on particle size distributions. 

Particle-Size Distribution This is defined as the relative percentage by weight of grains of each of the different size fractious represented in the sample. It is one of the most important factors in evaluating a screening operation and is best determined by a complete size analysis using testing sieves. 

In addition to the great dependence of MIE on particle size distribution and the possible accumulation of additives, complicating factors in measuring and applying MIE data include the presence of flammable gas (6-1.3.1) plus the effects of moisture (6-1.6) and possibly increased temperature (6-1.5) relative to the test temperature. 

Mean particle diameter The mean value of the particle size distribution of the test aerosol. 

All packing materials produced at PSS are tested for all relevant properties. This includes physical tests (e.g., pressure stability, temperature stability, permeability, particle size distribution, porosity) as well as chromatographic tests using packed columns (plate count, resolution, peak symmetry, calibration curves). PSS uses inverse SEC methodology (26,27) to determine chromatographic-active sorbent properties such as surface area, pore volume, average pore size, and pore size distribution. Table 9.10 shows details on inverse SEC tests on PSS SDV sorbent as an example. Pig. 9.10 shows the dependence... 

The tests that reflect physical properties of the catalyst are surface area, average bulk density, pore volume, and particle size distribution. 

Comparison Between Three Test Methods for Particle Size Distribution of... 

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