Paroxetine

SSRIs are widely used for treatment of depression, as well as, for example, panic disorders and obsessive—compulsive disorder. These dmgs are well recognized as clinically effective antidepressants having an improved side-effect profile as compared to the TCAs and irreversible MAO inhibitors. Indeed, these dmgs lack the anticholinergic, cardiovascular, and sedative effects characteristic of TCAs. Their main adverse effects include nervousness /anxiety, nausea, diarrhea or constipation, insomnia, tremor, dizziness, headache, and sexual dysfunction. The most commonly prescribed SSRIs for depression are fluoxetine (31), fluvoxamine (32), sertraline (52), citalopram (53), and paroxetine (54). SSRIs together represent about one-fifth of total worldwide antidepressant unit sales. 

Risperidone (11) was also included among a a 1-adrenergic receptor antagonists to study a quantitative structure-activity relationship (99BMC2437). A pharmacophore model for atypical antipsychotics, including 11, was established (00MI41). An increased plasma level of 11 and 9-hydroxyrisperidone (12) was observed in combination with paroxetine (01 MI 13). The effect of vanlafaxine on the pharmacokinetics of 11 was reported (99MI13). 

Antidepressants are used in the treatment of neuropathic pain and headache. They include the classic tricyclic compounds and are divided into nonselective nor-adrenaline/5-HT reuptake inhibitors (e.g., amitriptyline, imipramine, clomipramine, venlafaxine), preferential noradrenaline reuptake inhibitors (e.g., desipramine, nortriptyline) and selective 5-HT reuptake inhibitors (e.g., citalopram, paroxetine, fluoxetine). The reuptake block leads to a stimulation of endogenous monoaminer-gic pain inhibition in the spinal cord and brain. In addition, tricyclics have NMDA receptor antagonist, endogenous opioid enhancing, Na+ channel blocking, and K+ channel opening effects which can suppress peripheral and central sensitization. Block of cardiac ion channels by tricyclics can lead to life-threatening arrhythmias. The selective 5-HT transporter inhibitors have a different side effect profile and are safer in cases of overdose [3]. 

Selective serotonine reuptake inhibitor (SSRI) is an abbreviation for the class of antidepressants known as the Selective Serotonin Reuptake Inhibitors. Examples of SSRIs include fluoxetine, paroxetine, citalopram, and sertraline. These drugs selectively inhibit the serotonin transporter thus prolonging the synaptic lifespan of the neurotransmitter serotonin. 

Indeed, 5-HT is also a substrate for the 5-HT transporter, itself an important player in the treatment of depression, and more recently for the whole range of anxiety disorders spectrum (GAD, OCD, social and other phobias, panic and post-traumatic stress disorders). It is the target for SSRIs (selective serotonin reuptake inhibitors) such as fluoxetine, paroxetine, fluvoxamine, and citalopram or the more recent dual reuptake inhibitors (for 5-HT and noradrenaline, also known as SNRIs) such as venlafaxine. Currently, there are efforts to develop triple uptake inhibitors (5-HT, NE, and DA). Further combinations are possible, e.g. SB-649915, a combined 5-HTia, 5-HT1b, 5-HT1d inhibitor/selective serotonin reuptake inhibitor (SSRI), is investigated for the treatment of major depressive disorder. 

C73H,305 39932-51-9) see Cortivazol IV, -dimethyl-1,2-diphenyl-l,2-ethanediamine (CkjHjqNj 22757-6i i-V) see Paroxetine dimethyl(3,3-diphenyltetrahydro-2-furylidene)ammoni-um bromide... 

C5H7NO2 105-56-6) see Allopurinol Amlexanox Bemegride Ethosuximide Etozolin Folic acid Gabapentin Paroxetine Phensuximide Sulfadimethoxine Theophylline Tinoridinc Trimethoprim Valdetamide Valproic acid ethyl 2-(2 -cyanobiphenyl-4-ylmethylamino)-3-nitroben-zoate... 

CjnHjzFNOj 110429-36-2) see Paroxetine 1 -(4-fluorophenyl)-S-chloro- Iff-indole (C14H9CIFN 138900-22-8) see Sertindole... 

C10H20O 2276-57-5) see Paroxetine (+)-menthyl benzoate (C17H24O2 38649-18-2) see (-)-Menthol ( )-mepromazine... 

C14HUFNO2) see Paroxetine A/-methylformanilide (C,H, NO 93-61-8) see Benzoctamine methyl formate... 

C7H5CIO2 1885-14-9) see Alacepril Camazepam Itraconazole Paroxetine t>-phenyl chlorothioformate (C7H5CIOS 1005-56-7) see Cladribine 4-phenylcinnoline... 

CHjNaO 124-41-4) see Atorvastatin calcium Brinzolamide Ciprofloxacin Cisapride Dextrothyroxine Epirizole Hydroxyprogesterone Metaclazepam Moxifloxacin hydrochloride Moxonidine Oxcarbazepine Pantoprazole sodium Sulfadimethoxine Sulfalene Sulfamcthoxypyridazine Tacrolimus Vincamine sodium 3,4-(methylenedioxy)phenolate (CjHjNaOj 57f74-0i-5) sec Paroxetine sodium 4-nitrophenolate... 

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