Brain from paroxetine

A summary of these data on monoamine uptake inhibition and on inhibition of binding by rat brain synaptosomes of the selective 5-HT uptake inhibitor paroxetine and the selective NE uptake inhibitor tomoxetine taken from [53] is shown in table 5. Although the eudismic ratio (potency less active isomer/potency active isomer) of the R and S isomers of fluoxetine is fairly dose to one i.e. 1.58, the selectivity index (antilog (pl 5-HT - Pkj NE) of the S isomer is much larger than that of the R isomer. In offier words the R isomer of fluoxetine is a less selective 5-HT uptake inhibitor than the S isomer but their potendes are similar. This is also confirmed by the data on the inhibition of H-paroxetine and H-tomoxetine binding. 

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