Zolpidem Paroxetine

Becanse this patient was nsing other medications (paroxetine, Zolpidem, and snmatriptan), which can have a similar effect, this report reqnires confirmation. 

Katz SE. Possible paroxetine-zolpidem interaction. Am J Psychiatry 995 ) 152,1689. 

Omeprazole, like cimetidine, can impair benzodiazepine metabolism and lead to adverse effects (SEDA-18, 43). Other drugs, including antibiotics (erythromycin, chloramphenicol, isoniazid), antifungal drugs (ketoconazole, itraconazole, and analogues), some SSRIs (fluoxetine, paroxetine), other antidepressants (nefazodone), protease inhibitors (saquinavir), opioids (fentanyl), calcium channel blockers (diltiazem, verapamil), and disulfiram also compete for hepatic oxidative pathways that metabolize most benzodiazepines, as well as zolpidem, zopiclone, and buspirone (SEDA-22,39) (SEDA-22,41). 

FLUOXETINE, PAROXETINE, SERTRALINE, VENLAFAXINE ZOLPIDEM Cases of agitation hallucinations Uncertain Avoid co-administration... 

Zolpidem A case of delirium has been reported when used in combination with paroxetine. 

Clinically important, potentially hazardous interactions with alfentanil, aminophylline, amisulpride, amoxicillin, ampicillin, anticonvulsants, astemizole, atorvastatin, benzodiazepines, bromocriptine, buprenorphine, bupropion, carbamazepine, cilostazol, ciprofloxacin, cisapride, clindamycin, colchicine, cyclosporine, dasatinib, digoxin, dihydroergotamine, diltiazem, disopyramide, enoxacin, eplerenone, ergotamine, eszopiclone, everolimus, fluconazole, fluoxetine, fluvastatin, gatifloxacin, HMG-CoA reductase inhibitors, imatinib, itraconazole, ketoconazole, lomefloxacin, lorazepam, lovastatin, methadone, methylprednisolone, methysergide, midazolam, mizolastine, moxifloxacin, nitrazepam, norfloxacin, ofloxacin, paroxetine, pimozide, pravastatin, quinolones, ranolazine, repaglinide, rupatadine, sertraline, sildenafil, simvastatin, sparfloxacin, sulpiride, tacrolimus, terfenadine, triazolam, troleandomycin, vardenafil, verapamil, vinblastine, warfarin, zaleplon, zolpidem, zuclopenthixol... 

There is some evidence to suggest that the metabolism of some benzodiazepines (such as alprazolam, bromazepam, diazepam, and also possibly midazolam, nitrazepam and triazolam) may be reduced by some SSRIs (such as fluoxetine and fluvoxamine). On the whole, no clinically significant interaction appears to occur between other SSRIs and the benzodiazepines or related dri s such as cloral hydrate or zaleplon. There is some evidence to support the su estion that sedation is likely to be increased by the concurrent use of SSRIs and benzodiazepines. Rare cases of hallucinations have been seen with zolpidem and some SSRb. Symptoms of the serotonin syndrome have been reported in two patients taking paroxetine and a benzodiazepine. 

An isolated report describes a healthy 16-year-old girl with depression who took paroxetine 20 mg daily for 3 days, and then on the evening of the third night a single 10-mg dose of zolpidem. Within 1 hour she began to hallucinate, then became disorientated and was unable to recognise members of her family. She recovered spontaneously within 4 hours. " ... 

Noninterfering acetaminophen, amineptine, amphotericin B, aspirin, bromazepam, buspirone, citalopram, clobazam, diazepam, didanosine, fluconazole, flunitrazepam, flu-voxamine, hydroxyitraconazole, isoniazid, itraconazole, lamivudine, loprazolam, lora-zepam, metronidazole, minalcipram, nordiazepam, omeprazole, paroxetine, pyrimethamine, rifampin, sertraline, stavudine, sulfadiazine, trimethoprim, venlafaxine, zal-citabine, zidovudine, zolpidem, zopiclone... 

Thieme, D. Sachs, H. Improved screening capabilities in forensic toxicology by application of liquid chromatography-tandem mass spectrometry, Anal.ChimActa, 2003, 492, 171-186. [hair LC-MS alprazolam dothiepin piritramide cocaine lorazepam lormetazepam clonazepam flimitrazepam bromazepam midazolam flurazepam nitrazepam temazepam medazepam nordazepam diazepam methylclonazepam triazolam oxazepam haloperidol benperidol sulpiride amisulpride mirtazapine citalopram olanzapine paroxetine fluoxetine sertraline zopiclone zolpidem risperidone quetiapine fentanyl pipamperone meperidine buprenorphine propoxyphene pentazocine phenazocine EDDP ... 

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