Paroxetine beta-blockers

Drugs that may affect phenothiazines include anticholinergics, beta-blockers, meperidine, paroxetine, ritonavir, and thiazide diuretics. 

IMATINIB 1. ANTIARRHYTHMICS -flecainide, mexiletine, propafenone 2. ANTIDEPRESSANTS - fluoxetine, paroxetine, TCAs, trazodone, venlafaxine 3. ANTIPSYCHOTICS -clozapine, haloperidol, perphenazine, risperidone, thioridazine 4. BETA-BLOCKERS - metoprolol, propanolol, timolol 5. DONEPEZIL 6. METHAMPHETAMINE Imatinib may cause t plasma concentrations of these drugs, with a risk of toxic effects Inhibition of CYP2D6-mediated metabolism of these drugs Watch for early features of toxicity of these drugs... 

Discrete performance anxiety (stage fright) most common phobia, treat with atenolol or propranolol (beta blocker) or paroxetine (SSR1)... 

ANTICOAGULANTS - ORAL 5. ANTIDEPRESSANTS - mianserin, paroxetine 6. ANTIDIABETIC DRUGS - repaglinide, sulphonylureas 7. ANTIEMETICS - aprepi-tant 5-HT3-antagonists 8. ANTIFUN-GALS - fluconazole, itraconazole, ketoconazole, voriconazole 9. ANTIPSY-CHOTICS - apiprazole, chlorpromazine, haloperidol 10. BETA-BLOCKERS-metoprolol, propanolol, timolol... 

Fluoxetine and paroxetine inhibit the cytochrome P450 isoenzyme CYP2D6 thus inhibiting the metabolism of some beta blockers (e.g. propranolol, metoprolol, carvedilol) so that they accumulate, the result being that their effects, such as bradycardia, may be increased. Citalopram and escitalopram may also inhibit CYP2D6. In vitro studies with human liver microsomes found that fluoxetine and paroxetine are potent inhibitors of metoprolol metabolism and fluvoxamine, sertraline and citalopram less potent. However, fluvoxamine also potently inhibits the metabolism of propranolol by CYP1A2. Beta blockers that are not extensively me-... 

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