Pancreatic polypeptide receptors

When the human PP1/Y4 receptor was stably expressed in CHO cells, it inhibited forskolin-stimulated cAMP accumulation by 50% in response to human PP at 100 nM with EC50 at 7 nM (Lundell et al., 1995). In mouse fibroblasts (thymidine kinase 

The 5 -untranslated region of the PP1/Y4 gene has not yet been investigated to see if any introns are present. 

---

Michel MC, Beck-Sickinger AG, H Cox et al (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY and pancreatic polypeptide receptors. Pharmacol Rev 50 143-150... 

Lundell, I., Statnick, M.A., Johnson, D., Schober, D.A., Starback, R., Gehlert, D. Larhammar, D. (1996) The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous human receptor. Proc. Natl Acad. Sci USA 93, 5111-5115. 

Schwartz, T.W., Fuhlendorff, J., Kjems, L.L., Kirstensen, M.S., Vervelde, M., O Hare, M., Krstenansky, J.L. Bjornholm, B. (1990) Signal epitopes in the three-dimensional structure of neuropeptide Y interaction with Y1, Y2 and pancreatic polypeptide receptors. Ann. N. York Acad. Sci. 611, 35-47. 

Bard, J.A., Walker, M.W., Branchek, T. Weinshank, R.L. (1995a) DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof. International patent application WO 95/17906,... 

The hormone pancreatic polypeptide (PP) is a 36 amino acid peptide, which is closely related to neuropeptide Y and peptide YY PP is mainly found in pancreatic cells distinct from those storing insulin, glucagon or somatostatin. It acts on receptors that belong to the family of neuropeptide Y receptors, particularly on the Y4 subtype. 

Pancreatic Polypeptide Nuclear Receptor Regulation of Hepatic Cytochrome P450 Enzymes... 

The neuropeptide Y (NPY) belongs to a family of peptides that includes peptide YY and pancreatic polypeptide, and it is associated with several diseases such as asthma, immune system disorders, inflammatory diseases, anxiety, depression and diabetes mellitus. NPY is found in the central and peripheral nervous system, and its biological functions are mediated by interactions with five receptor sub-types, i.e. Yl, Y2, Y4, Y5 and Y6. Several studies indicate that the feeding behavior is influenced by interactions between NPY and Yl and Y5. Deswal and Roy used Cerius descriptors and genetic function approximation QSAR to investigate the structural determinants for the inhibition potency of 24 compounds with the general structure 4 for the NPY Y5 receptor [31]. The best QSAR (H = 0.720,... 

Neuropeptide Y (NPY) is a highly conserved 36 amino acid peptide of the pancreatic polypeptide family that is widely distributed throughout the mammalian brain. Y1 and Y2 receptors represent the major subtypes expressed in brain areas known to be activated upon anxiogenic stimulation, thus providing the rationale for studying the involvement of NPY and its receptor subtypes in anxiety-related behaviour (Kask et al. 2002). Other receptor subtypes in... 

D. Larhammar (1996). Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide. Regul. Pept. 65 165. 

These diverse effects are mediated by multiple receptors designated Y through Y 6. All receptors except Y3 have been cloned and shown to be G protein-coupled receptors linked to mobilization of Ca2+ and inhibition of adenylyl cyclase. Yj and Y2 receptors are of major importance in the cardiovascular and other peripheral effects of the peptide. Y4 receptors have a high affinity for pancreatic polypeptide and may be a receptor for the pancreatic peptide rather than for NPY. Y5 receptors are found mainly in the central nervous system and... 

Neuropeptide Y and its presynaptic receptors were discovered 25 years ago (Figure 1). There are four subtypes of neuropeptideY receptors, Yi, Y2, Y4 and Y5 (Table 1, Alexander et al. 2006) a fifth subtype, Y6, is functional in the mouse, whereas in primates the related gene is nonfunctional due to a frame-shift mutation (Alexander et al. 2006). Neuropeptide Y receptors are also activated by another two peptides, peptide YY (PYY) and pancreatic polypeptide (PP). The three peptides are not synthetized as such but are processed from larger precursors via two steps, i.e., an initial cleavage of the N-terminal signal peptide and the subsequent cleavage of the C-terminal part (Tatemoto 2004). The affinity of PYY is very similar to that... 

Neuropeptide Y (NPY) receptors are a class of G-protein-coupled receptors that are activated by the closely related peptide hormones NPY, peptide YY and pancreatic polypeptide. These receptors are involved in control of a diverse set of behavioural processes, including appetite, circadian rhythm and anxiety. AgRP is a receptor antagonist of CNS melanocortin receptors and appears to have an important role in the control of food intake. Hypothalamic POMC neurons are important mediators in the regulation of feeding behaviour, insulin levels and ultimately body weight. 

Pancrease pancreatin rizolipase. pancreatic polypeptide (PP) is an amidated peptide with a sequence that differs in human, rat, avian, frog and salmon forms. PP belongs to a family of peptides with a number of emerging members. Including neuropeptide Y (NPY) and peptide YY (PYY). These peptides appear to share a number of receptors. PP is a NEUROPEPTIDE Y RECEPTOR AGONIST. 

Jorgensen, J.Ch., Fuhlendorff, J. Schwartz, T.W. (1990) Structure-function studies on neuropeptide Y and pancreatic polypeptide - evidence for two PP-fold receptors in vas deferens. Eur.J. Pharmacol. 186, 105-114. 

---