P2-microglobulin

P2-microglobulin concentration have been correlated with survival. The International Index is a predictive model for aggressive NHL to be treated with doxorubicin-containing chemotherapy regimens.11 This index is used as a tool for selecting therapy for patients who may warrant a more intense treatment regimen based on known poor prognostic factors. 

P2 Microglobulin A low-molecular-weight protein that may be elevated in multiple myeloma. 

Figure 4. AFM micrograph of a saturated monolayer of antibodies against p2-microglobulin measured in phosphate buffered saline (PBS) solution using tapping mode. The dark window shows the underlying polystyrene surface obtained by wipping off the antibodies.

Table 2. Responses of a grating coupler sensor coated with multilayers of monoclonal antibodies to the respective analytes. The response values are related to that of an adsorbed antibody monolayer (B2M p2-microglobulin, HCG human choriogonadotropin, HRP horseradish peroxidase.

Brynda E., Elouska M., Brandenburg A., Wikerstal A., Skvor J., The detection of human P2-microglobulin by grating coupler immunosensor with three-dimensional antibody networks, Biosens. Bioelectron. 1999 14 363-368. 

P2-Microglobulin 0.002 11.8 Associated with human leukocyte antigen... 

Assessing the Effect of DE-Loop Mutation (D59P) in the Amyloid Aggregation Propensity of p2-Microglobulin with Molecular Dynamics Simulations... 

Class I MHC proteins occur in almost all nucleated cells. They mainly interact with cytotoxic T cells and are the reason for the rejection of transplanted organs. Class 1 MHC proteins are heterodimers (a 3). The p subunit is also known as P2-microglobulin. 

Mica unmodified Hydrophilic and negatively charged Contact angle <10ob Recombinant p2-microglobulin No growth observed Relini et al. (2006) Yang et al. (2007)... 

Studies of renal function in chrome platers, whose exposure is mainly to chromium(VI) compounds, have also yielded equivocal results. A positive dose-response for elevated urinary levels of p2-microglobulin was found in chrome platers who were exposed to 0.004 mg chromium(VI)/m3, measured by personal air... 

Studies of renal function in stainless steel welders, whose exposure is mainly to chromium(VI) compounds, were negative. Stainless steel welders had significantly increased (p<0.001) levels of urinary chromium, increased clearance of chromium, and increased serum creatinine compared with controls, but no differences were found in the levels of retinol binding protein, p2-microglobulin or other indices of kidney damage (Verschoor et al. 1988). Similar negative results were found in another group of stainless steel welders (Littorin et al. 1984). 

Occupational exposure to chromium(III) or chromium(O) does not appear to be associated with renal effects. No renal impairment based on urinary albumin, retinol binding protein, and renal tubular antigens was found in 236 workers employed in the ferrochromium production industry where ferrochromite is reduced with coke, bauxite, and quartzite. The mean airborne concentration of chromium in various sample locations was 0.075 mg chromium(III)/m3 chromium(VI) was below the detection limit of 0.001 mg chromium(VI)/m3 at all locations (Foa et al. 1988). Workers employed in an alloy steel plant with a mean exposure of 7 years to metallic chromium at 0.61 mg chromium(0)/m3 and to other metals had normal urinary levels of total protein and p2-microglobulin, enzyme activities of alanine-aminopeptidase, N-acetyl-P-D-glucosaminidase, gammaglutamyl-transpeptidase, and P-galactosi-dase (Triebig et al. 1987). In boilermakers exposed to chromium(O), no increase in urinary levels of... 

Estimation of the glomerular filtration rate (GFR) is considered a sensitive index of functional nephron mass (Newman and Price 1999). Point measurements of the plasma levels of several endogenous small molecules (urea, creatinine, 2-(a-mannopyranosyl)-L-tryptophan) or small (less than 66 kDa) proteins (cystatin C (y-trace), prostaglandin D synthase (15-trace protein), ai-microglobulin, p2-microglobulin, and retinol binding protein) have been used to assess GFR in many species. 

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