P27/Kipl

Durand B, Gao FB, Raff M 1997 Accumulation of the cyclin-dependent kinase inhibitor p27/ Kipl and the timing of oligodendrocyte differentiation. EMBO J 16 306-317 Durand B, Fero ML, Roberts JM, Raff MC 1998 p27Kipl alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation. Curr Biol 8 431-440... 

Kiyokawa H, Kineman RD, Manova-Todorova KO et al 1996 Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kipl). Cell 85 721—732 KondoT, RaffM 2000a The Id4 HLH protein and the timing of oligodendrocyte differentiation. EMBO J 19 1998-2007... 

NakayamaK, IshidaN, Shirane Metal 1996 Mice lacking p27(Kipl) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85 707-720... 

Nahum, A., K. Hirsch, M. Danilenko et al. 2001. Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kipl) in the cyclin E-cdk2 complexes. Oncogene 20(26) 3428-3436. 

Tsvetkov, L. M., et ah, p27(Kipl) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thrl87 in p27. Curr Biol, 1999, 9(12), 661-4. 

Nakayama, K., et al., Targeted disruption of Skp2 results in accumulation of cydin E and p27(Kipl), polyploidy and centrosome overduplication. EmboJ, 2000, 19(9), 2069-81. 

Shieane, M., et al.. Down-regulation of p27(Kipl) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing. J Biol Chem, 1999, 274(20), 13886-93. 

Mamillapalli, R., et al., PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIPl) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol, 2001, 11(4), 263-7. 

Moeimoto, M., Nishida, T., Honda, R. and Yasuda, H. Modification of cullin-1 by ubiquitin-like protein NeddS enhances the activity of SCE(skp2) toward p27(kipl). Biochem Biophys Res Commun 2000, 270, 1093-6. 

Moneo V, Serelde BG, Leal JFM, Blanco-Aparicio C, Diaz-Uriarte R, Aracil M, Tercero JC, Jimeno J, Camero A. (2007) Levels of p27(kipl) determine Aplidin sensitivity. Mol Cancer Ther 6 1310-1316. 

Nguyen, H., Gitig, D. M., and Koff, A. (1999). Cell-free degradation of p27(kipl), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome. Mol Cell Biol 19, 1190-1201. 

Using 2D-PAGE, cell cycle entry has been shown to be associated with a significant increase in p27(kipl) phosphorylation in human primary B lymphocytes. Detailed analysis revealed that different cyclins and cyclin-dependent kinases interact with distinct posttranslationally modified isoforms of p27(kipl) in vivo. These results have to be interpretated in the context of overexpression of cyclin D3 in the presence of high levels of p27(kipl) in human B-cell lymphomas with adverse clinical outcome [110]. 

Milde-Langosch K, Bamberger AM, Methner C, Rieck G, Loning T. Expression of cell cycle-regulatory proteins rb, pl6/MTSl, p27/KIPl, p21/WAFl, cyclin Dl and cyclin E in breast cancer correlations with expression of activating protein-1 family members. In t. J. Cancer 2000 87 468-472. 

Weiss RH, Ramirez A, Joo A. 1999. Short-term pravastatin mediates growth inhibition and apoptosis, independently of Ras, via the signaling proteins p27 Kipl and P13 kinase. J. Am. Soc. Nephrol. 10 1880-90... 

Tung EW, Winn LM (2011) Valproic acid-induced DNA damage increases embryonic p27(KIPl) and caspase-3 expression amech-anism for valproic-acid induced neural tube defects. Reprod Toxicol 32(3) 255-260... 

Erickson LA, Jin L, Wollen P, et al. Parathyroid hyperplasia, 84. adenomas and carcinomas differential expression of p27 Kipl protein. Am J Surg Pathol. 1999 23 288-295. 

Vis AN, van Rhijn BW, Noordzij MA, et al. Value of tissue markers p27(kipl), MIB-1, and CD44s for the pre-operative prediction of tumour features in screen-detected prostate cancer. J Pathol. 2002 197 148. 

Migita T, Oda Y, Naito S, Tsuneyoshi M. Low expression of p27(Kipl) is associated with tumor size and poor prognosis in patients with renal cell carcinoma. Cancer. 2002 94 973. 

Schonherr E, Levkau B, Schaefer L, Kresse H, Walsh K. Decorin-mediated signal transduction in endothelial cells. Involvement of Akt/protein kinase B in up-regulation of p21(WAFl/CIPl) but not p27(KIPl). J Biol Chem 2001 276 40687-40692. 

Pandhare-Dash J, Mantri CK, Gong Y, Chen Z, Dash C. XMRV accelerates cellular proliferation, transformational activity, and invasiveness of prostate cancer cells by downregulating p27(Kipl). Prostate. 2012 72 886-97. 

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