Ubiquitin-mediated degradation

Shieane, M., et al.. Down-regulation of p27(Kipl) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing. J Biol Chem, 1999, 274(20), 13886-93. 

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRSl and 1RS2. / Biol Chem 2002, 277, 42394-8. 

Carrano, A. C., Eytan, E., Hershko, A. and Pagano, M. (1999). Skp2 is required for ubiquitin-mediated degradation of the Cdk inhibitor p27. Nature Cell Biol. 1, 193-199. 

Carrano AC, E an E, Hershko A, Pagano M (1999) SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nature Cell Biol 1 193-199 Cendarelli C, Hou D, Hsu KC, Rellahan BL, Wiest DL, Smith HT, Fried VA, Weissman AM 0992) Activation-induced ubiquitination of the T cell antigen receptor. Science 257 795-797... 

DNA-PK E6AP Kinase/UV E6 accessory protein/ubiquitin-mediated degradation... 

The examples in previous sections have demonstrated the importance of signal-induced phosphorylation in modulating the activity of many transcription factors. Another mechanism for regulating transcription factor activity in response to extracellular signals was revealed in studies with both mammalian cells and Drosophila. This mechanism, which involves phosphorylation and subsequent ubiquitin-mediated degradation of an Inhibitor protein, is exemplified by the NF-kB transcription factor. 

The ubiquitin-mediated degradation of intracellular proteins is a universal phenomenon in eukaryotic cells that is fundamental to the regulation of various cell processes. In 2004, Aaron Ciechanover, Avram Hershko, and Irwin Rose shared the Nobel Prize in chemistry for their discovery of this pathway. 

Izzi, L. and Attisano, L. 2004. Regrdation of the TGF signaUing pathway by ubiquitin-mediated degradation. Oncogene, 23, 2071-2078. 

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