Oxymetazoline nasal spray

Each milliliter of Afrin Original Nasal Spray and Pump Mist contains oxymetazoline hydrochloride, 0.05%. It also contains benzalkonium chloride, edetate disodium, poly- 

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A 43-year-old woman with hypertension and diabetes meUitns nsed 2-3 pnffs of oxymetazoline nasal spray and experienced painless blnrring of vision in the right eye, with a corrected acnity of 20/400 (20/50 on the left). Apart from backgronnd diabetic retinopathy she had edema of the optic disk. Several weeks later she nsed the spray again and this time developed blurred vision in the left eye. There was disk pallor on both sides and acuities were 20/400 on the right and 20/70 on the left. There were also segmental inferior field defects in both eyes. After 6 weeks both eyes had recovered somewhat, but only to 20/200 and 20/50 respectively there was no further improvement after a year. 

The development of an acute retinal artery obstruction in a young, otherwise healthy man was associated with excessive use of an oxymetazoline nasal spray. Platelet coagulation studies indicated a platelet aggregation hypersensitivity to adenosine diphosphate and adrenaline. Predisposition to sympathomimetic drug-induced platelet fibrin embolus formation may have played a role in this case (2). 

Oxymetazoline (Afrin, Visine, many others). This drug is used in nose drops and nasal sprays to decrease nasal congestion through alpha- 1-mediated vasoconstriction. Higher or systemic doses may also cause hypotension, presumably because central nervous system (CNS) alpha-2 receptors are stimulated in a manner similar to clonidine (see Alpha-2-Selective Agonists ). Oxymetazoline can also be administered as eye drops to decrease redness and minor eye irritation. 

Oxymetazoline Afrin, Dristan 12-Hr Nasal Spray, others Nasal spray... 

An unusual response to an overdose of oxymetazoline (0.05% nasal spray) occurred in an elderly patient who used the product several times daily the patient, who had pre-existing cerebellar degeneration and peripheral neuropathy, developed severe bradycardia and oscillations in systolic pressure between 236 and 60 mmHg. Withdrawal of the spray resulted in complete recovery (6). 

NEO-SYNEPHRINE 12 h Bayer (U.S.) Oxymetazoline HCI 0.05% BKC, phenylmercuric acetate (0.002%), glycine, sorbitol Nasal spray bottle... 

The client who has been using oxymetazoline (Afrin) nasal spray for several weeks complains to the nurse that the spray no longer seems to work to clear the nasal passages. Which information should the nurse teach ... 

The clinic nurse is discussing over-the-counter (OTC) oxymetazoline (Afrin 12 Hour Nasal Spray), a sympathomimetic, with a client experiencing nasal congestion. 

Nasal decongestant sprays such as phenylephrine and oxymetazoline that reduce inflammation by vasoconstriction are often used in sinusitis. Use should be limited to the recommended duration of the product to prevent rebound congestion. Oral decongestants may also aid in nasal or sinus patency. To reduce mucociliary function, irrigation of the nasal cavity with saline and steam inhalation may be used to increase mucosal moisture, and mucolytics (e.g., guaifenesin) maybe used to decrease the viscosity of nasal secretions. Antihistamines should not be used for acute bacterial sinusitis in view of their anticholinergic effects that can dry mucosa and disturb clearance of mucosal secretions. 

OXYMETAZOLINE HYDROCHLORIDE NASAL SOLUTION 15ML SPRAY BOTTLE 6505008694177 BT 4.16 ... 

Oxymetazoline (Afrin) Nasal deconges- rrg Soln spray 0.05%... 

Nasal formulations of modern sympathicomimet-ics like oxymetazoline and xylometazoline are effective. Rebound nasal congestion after withdrawal of sympathicomimetic-containing nose sprays or drops is a common phenomenon and patients should be advised to use these medicaments no longer than 3-5 days. Older per oral drugs like ephedrine and pseudo-ephedrine have no place in the therapy of rhinitis due to the risk of serious adverse reactions which are not in proportion to the indication. 

Data regarding supportive therapy are limited, but such therapy may be useful. Nasal decongestant sprays such as phenylephrine and oxymetazoline that reduce inflammation by vasoconstriction are used often in sinusitis." " " " Use should be limited to the recommended... 

AFRIN (DURATION Schering-Plough QJ.S.) Oxymetazoline 0.05% Nasal decongestant BKC, Na2edta, PEG1450, pov, PG, NaP Plastic squeeze bottle Spray pump bottle... 

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