Oxidant-induced apoptosis

Messmer, U.K. and Brune, B., Nitric oxide-induced apoptosis p53-depedent and p53-inde-pendent signalling pathways, Biochem. J., 319, 299, 1995. 

Nitric oxide-induced apoptosis in human leukemic lines requires mitochondrial hpid degradation and cytochrome c release. Blood 93 2342-2352. 

Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial Upid degradation and cytochrome c lelease. Blood, 93 2342-2352 Wendel, A., 1981, Glutathione peroxidase. Methods Enzymol. 77 325-333... 

Recently, we also documented that PS oxidation during oxidant-induced apoptosis occurred within the plasma membrane, the largest source of oxidized PS compared to other cellular organells (Kawai et al, 2000). 

LCLs derived from targeted populations have been utilized to evaluate genetic susceptibility to radiation sensitivity (9), sensitivity to mitomycin C in patients with Wilms tumor (10), and camptothecin-induced apoptosis (11). These cell lines have been useful for studying bleomycin-induced chromatid breaks and oxidant-induced apoptosis (12)... 

Selegiline increases the striatal superoxide dismutase, protects against peroxynitrite- and nitric-oxide-induced apoptosis, and guards dopaminergic neurons from toxicity induced by glutathione depletion. 

PROTECTION BY SELEGILINE AGAINST PEROXYNITRITE- AND NITRIC-OXIDE-INDUCED APOPTOSIS... 

Since in all these cases we used oxidants to induce apoptosis, a relatively massive background oxidation of all PnA-labeled phospholipid classes was observed and masked apoptosis-specific PS oxidation. Therefore, we next determined whether a non-oxidant-induced apoptosis model could be used to reveal more explicitly the selective mode of PS oxidation inherent to the apoptosis execution program. To this end, we used agonistic anti-Fas antibody to induce apoptosis in Jurkat B cells according to a commonly used protocol (Fadeel et al., 1999). Importantly, we foundthat anti-Fas-triggered apoptosis in Jurkat cells was characterized by early and selective oxidaiton of cA-PnA-PS (Kagan et al., 2001) without any significant involvement of other classes of phospholipids. 

The discussion about the mechanism of excessive iodine supplementation-induced apoptosis remains controversial, there are several viewpoints (1) molecular iodine (intermediate products of oxidation) induces apoptosis (Golstein and Dumont, 1996) (2) reactive oxygen species (ROS) induce apoptosis (Vitale et al., 2000) (3) Fas—FasL induce apoptosis (Tamura et al, 1998 Feldkamp et al., 1999) (4) inhibition of Bcl-2 expression and an increase in Bax expression induce apoptosis (Yang et al., 2000) and (5) blocking the cell cycle of GO/Gl and G2/M induces apoptosis (Smerdely et al, 1993). 

Kuo ML, Chau YP, Wang JH et al. Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells. Biochem Biophys Res Commun 1996 219(2) 502-508. 

M. Yoshida, K. Nakayama, H. Yasuda, H. Kuho, K. Kuwano, H. Aral, M. Yamaya, Carhocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells, Respirology 14 (7) (September 2009) 1027—1034. 

Pervin, S., Singh, R., Freije, W.A., Chaudhuri, G. (2003). MKP-l-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines implications in breast cancer. Cancer Res. 63, 8853-8860. 

Wen, J.C., Chaudhuri, G., and Pervin, S. (2006). An inverse interaction between survivin and MAP kinase phosphata.se 1 regnlates nitric oxide-induced apoptosis. J. Invest Med. 54, S145-S145 (abstract). 

Gansauge, S., Nussler, A.K., Beger, H.G., and Gansauge, F. (1998). Nitric oxide-induced apoptosis in human pancreatic carcinoma cell lines is associated with a Gl-arrest and an increase of the cyclin-dependent kinase inhibitor p21WAFl/CIPl. Cell Growth Differ. 9,611-617. 

Jeon, H.K., Choi, S.U., and Jung, N.P. (2005). Association of the erkl/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells. Cell Biol. Toxicol. 21, 115-125. 

Lim, S., Hung, A.C., and Porter, A.G. (2009). Focused per screen reveals p53 dependence of nitric oxide-induced apoptosis and up-regulation of maspin and plasminogen activator inhibitor-1 in tumor cells. Mol. Cancer Res. 7,55-66. 

Fehsel, K., Kroncke, K.D., Meyer, KJ., Huber, H., Wahn, V., and Kolbbachofen, V. (1995). Nitric Oxide Induces Apoptosis In Mouse Thymocytes. J. Immunol. 155,2858-2865. 

Nishikawa, M., Sato, E.F., Kuroki, T., Utsumi, K., and Inoue, M. (1998). Macrophage-derived nitric oxide induces apoptosis of rat hepatoma cells in vivo. Hepatology. 25(6), 1474—1480. 

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