Ovarian lymphoma

Although the ovaries are not infrequently found to be involved by malignant lymphoma at autopsy, enlargement of the ovaries is rare. Less than 1% of patients with lymphoma initially present with unilateral or bilateral ovarian tumors [61]. Ovarian lymphoma is almost always a manifestation of a systemic disease, most commonly of B-cell lymphomas. Primary lymphoma of the ovary without lymph node or bone marrow involvement is extremely rare. It is encountered most commonly in premenopausal women. 

Ovarian cancer may resemble ovarian lymphoma. Bilateral involvement is most commonly found in... 

Thiotepa is chemically less reactive than the nitrogen mustards. It has antineoplastic activity against ovarian and breast cancers as well as lymphomas. However, it has been largely supplanted by cyclophosphamide and other nitrogen mustards. 

Liposomal encapsulation of DOX or DNR Preferred anthracycline delivery to the tumor Breast cancer, ovarian cancer, AIDS-related Kaposi s sarcoma, multiple myeloma (pegylated liposomal DOX). Breast cancer (uncoated liposomal DOX). AIDS-related Kaposi s sarcoma, acute mye-loblastic leukemia, multiple myeloma, non-Hodgkin s lymphomas (uncoated liposomal DNR)... 

As described in several monographs [4], bryostatin 1 exhibits significant in vitro and in vivo antineoplastic activity against a range of tumor cell lines including murine leukemia, B-cell lymphoma, reticulum cell sarcoma, ovarian carcinoma, and melanoma. It is also effective in the modulation of apoptotic function [5], the reversal of multidrug resistance [6], and stimulation of the immune system [7]. These unique features displayed by bryostatin 1 are attributed to its high affinity for protein kinase C (PKC) isozymes and its ability to selectively modulate their functions [8]. PKCs are a type of intracellular serine and threonine kinase that... 

Further studies have shown additional cancer types, most notably ovarian and bladder cancer, non-Hodgkin s lymphoma and acute myeloid leukaemia, to be at least partially responsive to IL-2 treatment. However, a persistent feature of clinical investigations assessing IL-2 effects on various cancer types is variability of response. Several trials have yielded conflicting results, and no reliable predictor of clinical response is available. 

Pancreatic Lung Breast (women only) Cervical and uterine Ovarian Prostate Kidney Non-Hodgkin s lymphoma Multiple myeloma Leukaemia (men only) Leukaemia (women only)... 

Anthracyclines Doxorubicin/ adriamycin Melanoma, Ovarian carcinoma, T-cell lymphoma, Colon carcinoma, B-cell lymphoma, Various disseminated refractory malignandes, Breast cancer, Lung cancer, Pancreatic cancer, Liver cancer, Neuroblastoma... 

Humanized and chimerized MAbs have been developed for the treatment of non-Hodgkin lymphoma, renal cell carcinoma, ovarian carcinoma, breast cancer, melanoma, and neuroblastoma [117,119,120,123,124]. Patients with relapsed or refractory myeloid leukaemias that have been treated with HuM95, did not develop significant HAMA responses [59]. 

Doxorubicin and dannorabicin are antibiotics made from microorganisms of the family Streptomyces peucetius. The stmcture of these anthracyclines contains an aminosaccarhide residue daunozamine attached to a naphthacenequinone nucleus. Doxorubicin differs from daunorubicin in the presence of a hydroxyl gronp at C14. A nnmber of mechanisms have been suggested in which anthracyclines exhibit cytotoxicity. They canse DNA to denature, are involved in oxidation-rednction reactions, chelate bivalent cations and react with cell membranes, changing their fnnction. They are used for severe leukemia, lymphoma, breast and ovarian cancer, and other solid tumors. 

Etoposide is used for germinogenic tumors, ovarian, stomach, and lung cancer, Hodgkin s disease, and non-Hodgkin s lymphoma for both monotherapy and in combination therapy. Synonyms of this drug are vepesid and others. 

Bleomycin is partially inactivated by bleomycin hydrolase present in various tissues. Some bleomycin-resistant cells contain high levels of hydrolase activity. Bleomycin is used in combination regimens for the treatment of lymphomas and in treating testicular, ovarian cancers and other solid tumors. 

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