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Chimeric mAbs

Humanized and chimerized MAbs have been developed for the treatment of non-Hodgkin lymphoma, renal cell carcinoma, ovarian carcinoma, breast cancer, melanoma, and neuroblastoma [117,119,120,123,124]. Patients with relapsed or refractory myeloid leukaemias that have been treated with HuM95, did not develop significant HAMA responses [59]. [Pg.222]

It is forecast that up to the end of the current decade, the research focus regarding therapeutic mAbs will be on two categories oncology and arthritis, and inflammatory and immune disorders. A significant increase of sales is expected up to 2008 for chimeric mAbs, in absolute terms, and for human and humanized mAbs, in relative terms (Figure 16.2). Up to now, murine mAbs are those with the lowest approval rate (4.5%), whereas the chimeric are the most successful (26%). The approval rates for humanized mAbs (18%) and human antibodies (14%) were intermediate. However, as most of the last two types are still under development, the approval situation may change significantly in the future (Reichert and Pavlou, 2004). [Pg.401]

Rituximab Rituxan Chimeric (hu/mu) anti-CD20 Chimeric Mab 11/26/1997... [Pg.577]

Dutton, G. (1991 b). Researchers exhibit increasing optimism over human and chimeric Mab development. Genetic Engineering News April, 1 26. [Pg.113]

Chimeric MAbs (her2, CD4, TNFa, CD20, CD18, TAC, leukointegrin, CF54, RSV) Others (TSH, TNF, M-CSF, IL-6, IL-1)... [Pg.221]

ReoPro (Abciximab, Fab fragments derived from a chimeric Mab, directed against the platelet surface receptor GPIIb/IIIa)... [Pg.357]

Rituxan (Rituximab chimeric Mab directed against CD 20 antigen found on the surface of B lymphocytes)... [Pg.359]

Simulect (Basiliximab, chimeric Mab directed against the a-chain of the IL-2 receptor)... [Pg.359]

Remicade (Infliximab, chimeric mAb directed against TNF-a) Centocor treatment of Crohn s disease 1998 (US), 1999 (EU)... [Pg.37]

Mabthera (Rituximab chimeric mAb directed against CD20 surface antigen of B lymphocytes) Hoffinann-La Roche (see also Rituxan) non-Hodgkin s lymphoma 1998 (EU)... [Pg.38]

Basiliximab Simulect Novartis chimeric mAb CD25 kidney transplant rejection 1998 IgGl <2%... [Pg.1151]

InfliKimab Remicade Johnson and Johnson chimeric mAb TNF-a rheumatoid arthritis, Crohn s disease, ankylosing spondylitis 1998, 1999 IgGl 13%... [Pg.1151]

Rituximab Rituxan Genentech, Biogen, I DEC, Hoffmann La Roche chimeric mAb CD20 non-Hodgkin s lymphoma 1997 IgGl <1%... [Pg.1151]

Cetuximab Erbitux ImClone, chimeric mAb epidermal colorectal cancer 2003 IgGl 5% of o... [Pg.1152]

Simplified structure of IgG molecules. Monoclonal antibodies (mAbs) consist of two heavy (H) and light (L) chains composed of a series of constant (C) and variable (V) region domains. Chimeric mAbs are composed of murine V region domains and C domains of human origin, while humanized mAbs only contain the murine amino acid sequences (represented by dotted bars) involved in antigen recognition... [Pg.2189]

See other pages where Chimeric mAbs is mentioned: [Pg.601]    [Pg.603]    [Pg.604]    [Pg.604]    [Pg.126]    [Pg.131]    [Pg.206]    [Pg.73]    [Pg.76]    [Pg.55]    [Pg.55]    [Pg.63]    [Pg.375]    [Pg.601]    [Pg.603]    [Pg.604]    [Pg.604]    [Pg.189]    [Pg.359]    [Pg.507]    [Pg.1655]    [Pg.1655]    [Pg.2019]    [Pg.495]    [Pg.239]    [Pg.67]    [Pg.2190]    [Pg.2190]    [Pg.140]    [Pg.437]    [Pg.438]   


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