Other Examples of Organometallics Complexes Tested for their Biological Activities

Other Examples of Organometallics Complexes Tested for their Biological Activities 

The following example illustrates the importance of the positioning of the organometallic group in order to obtain antiproliferative effects. 

The structural design of 68 seems to be the key to the problem. In fact, an electrochemical study has shown that the biological effect seems triggered by the reversible oxidation of the ferrocene entity, which could then be followed by a premature transformation of the phenol via generation of an intermediate carbenium ion, leading to a fairly stable quinone methide 70 [94], It is well documented that electrophilic species such as quinone methides have the potential to alkylate cellular macromolecules to produce a cytotoxic effect [151-153]. Complex 69, however, which is isolated in the form of the stable trans isomer, cannot produce a stabilized quinone methide. It is thus clear that for targeted organometaUic products such as 68 and 69, structural considerations come to the fore. 

Indeed, other aspects of organometaUic targeting for therapeutic application are rapidlyemerging. A particularly promising example is the role of certain metal 

The constraints and requirements (aqueous solvents, relative stability, rapid reaction time for radionucleides, selectivity, biological recognition, etc.) inherent in the synthesis of organometaUic molecules designed for biological targeting should not be viewed as an inhibitory factor in the development of the discipline, but instead as a spur to creativity. The chemist must often be prepared to leave the beaten track and explore new synthetic routes to the desired destination [161, 

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