Biological activity complexes

The technology for production of the biologically active complex probiotic preparations ProStor and Perm KM-1 is based on a partial solid phase... 

This study and its predecessors have made at least modest inroads into the largely uncharted territory of the intricate interplay between static interactions and their dynamics in determining the stability of biologically active complexes. They have also raised a host of new questions, which remain to be answered before we could claim to understand the mechanisms of allostery and induced fit. Massive collection of data will be necessary to achieve this end. A correlation between the affinity (thermodynamic stability) and dynamic stability of a complex remains to be established - whether one considers intramolecular -intra- and interchain - complexes that hold the protein together, or the intermolecular complexes of a protein with its ligands. The atomic motions reflected in such processes as nuclear relaxation and backbone proton exchange -the main NMR indicators of protein dynamics remain to be described. Last, not... 

The nature of the anion making up the Cr(III) salt, as well as the gastrointestinal tract contents and the nutritional status of the animal, are important determinants of efficiency of absorption from the gastrointestinal tract. For example, oxalates are better absorbed than phytates (Chen et al. 1973). There is a suggestion that biologically active complexes of Cr(III) are even better absorbed, perhaps to the extent of 10%-25% (Mertz and Roginski 1971). Zinc status also influences chromium absorption (Hahn and Evans 1975). Both Cr(III) and Cr(VI) salts are better absorbed in the fasting than in the fed state (Mackenzie et al. 1959). 

Gururaja and Waser describe the use of asymmetric phase-transfer catalysis for the synthesis of biologically active complex natural products in Chapter 14. In Chapter 15, ViUaverde et al. present an overview of the new trends in residue analysis, and the definition of biopesticide with reference to the European Regulation (EC) No. 1107/2009. 

Systems can possess different extents of complexity. To measure complexity, the information content of the system can be used. Application of information theory is increasingly finitful for modeling biological activities with regard to the symmetry of molecules. 

In the presence of [PtC ] and a base. 2-aminothiazole undergoes ring cleavage of the C-S bond to give PtLCF (L=HSCH=CHNHCN) (699). The Pd and Pt complexes of 2-aminothiazoles show biological activity (1596i. 

Human growth hormone is a very complex molecule biologically. Several diverse biological activities such as anaboHc, insulin-like, diabetogenic, and lactogenic activities have been ascribed to hGH, which also appears to promote water and salt retention. An in-depth discussion of these activities may be found in several excellent reviews available in the Hterature (34—36). 

Absorption, metaboHsm, and biological activities of organic compounds are influenced by molecular interactions with asymmetric biomolecules. These interactions, which involve hydrophobic, electrostatic, inductive, dipole—dipole, hydrogen bonding, van der Waals forces, steric hindrance, and inclusion complex formation give rise to enantioselective differentiation (1,2). Within a series of similar stmctures, substantial differences in biological effects, molecular mechanism of action, distribution, or metaboHc events may be observed. Eor example, (R)-carvone [6485-40-1] (1) has the odor of spearrnint whereas (5)-carvone [2244-16-8] (2) has the odor of caraway (3,4). 

There are three general types of radiopharmaceuticals elemental radionucHdes or simple compounds, radionucHde complexes, and radiolabeled biologically active molecules. Among the first type are radionucHdes in their elemental form such as Kr and Xe or Xe, and simple aqueous radionucHde solutions such as or I-iodide, Tl-thaUous chloride, Rb-mbidium(I) chloride [14391-63-0] Sr-strontium(II) chloride, and Tc-pertechnetate. These radiopharmaceuticals are either used as obtained from the manufacturer in a unit dose, ie, one dose for one patient, or dispensed at the hospital from a stock solution that is obtained as needed from a chromatographic generator provided by the manufacturer. 

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