Osawa studies

M. Fukuda, T. Kondo, and T. Osawa. Studies on the hydrazinolysis of glycoproteins. Core structures of oligosaccharides obtained from porcine thyroglobulin and pineapple stem bromelain. J. Biochem. 80 1223 (1976). 

Ataka, K. and Osawa, M. (1998) In situ infrared study of water-sulfate coadsorption on gold(l 11) in sulfuric acid solutions. Langmuir, 14, 951-959. 

Osawa, M Tsushima, M Mogami, H., Samjeske, G. and Yamakata, A. (2008) Structure of water at the electrified platinum-water interface a study by surface-enhanced infrared absorption spectroscopy. J. Phys. Chem. C, 112, 4248- 256. 

Samjeske G, Miki A, Ye S, Osawa M. 2006. Mechanistic study of electrocatal3dic oxidation of formic acid at platinum in acidic solution by time-resolved surface-enhanced infrared absorption spectroscopy. J Phys Chem B 110 16559-16566. 

Ayato Y, Kunimatsu K, Osawa M, Okada T. 2006. Study of Pt electrode/Nafion ionomer interface in HCIO4 by in situ surface-enhanced ETIR spectroscopy. J Electrochem Soc 153 A203-A209. 

Miki A, Ye S, Sensaki T, Osawa M. 2004. Surface-enhanced infrared study of catal)4ic electio-oxidation of formaldehyde, methyl formate, and dimethoxymethane on platinum electrodes in acidic solution. J Flectroanal Chem 563 23-31. 

Sun SG, Cai WB, Wan LJ, Osawa M. 1999. Infrared absorption enhancement for CO adsorbed on Au films in perchloric acid solutions and effects of surface structure studied by cyclic voltammetry, scanning tunneling microscopy, and surface-enhanced IR spectroscopy. J Phys Chem B 103 2460-2466. 

Shinoda K, Yagi H, Fujita H, Osawa Y, Shiotani Y. 1989. Screening ofaromatase-containing neurons in ratforebrain an immunohistochemical study with antibody against human placental antigen X-P2 (hPAX-P2). J Comp Neurol 290 502-515. 

Rao, R. R., and N. S. Jamir. Ethnobo-tanical studies in Nagaland. 1. Medicinal plants. EconBot 1982 36 176-181. Takahashi, M., K. Osawa, T. Sato, and ]. Ueda. Components of amino acids on Zingiber officinale Roscoe. Ann Rep Tohoku Coll Pharm 1982 29 75-76. John, D. One hundred useful raw drugs of the Kani tribes of Trivandrum Forest division, Kerala, India. Int J Crude Drug Res 1984 22(1) 17-39. 

N Ramarathnam, T Osawa, M Namikii, S Kawakishi. Chemical studies on novel rice hull antioxidants. 2. Identification of isovitexin, a C-glycosyl flavonoid. J Agric Food Chem 37 316-319,1989. 

PCP inhibits brain nitric oxide synthase irreversibly (Osawa and Davila, 1993 Jewett et al., 1996 Klamer et al., 2005). Depending upon its levels, nitric oxide acts as a neuroprotective or neurodestructive molecule (Lipton, 1993 Lipton et al., 1998). NMDA receptor antagonists that have treated ischemic injury of the brain in animal models with some benefit are presented in Tables 10.1 and 10.2. All studies on their use in humans have been unsuccessful because they not only block normal neuronal function, but also produce serious side effects such as headache, anxiety, agitation, nausea, vomiting, hallucinations, dizziness, and coma (Schehr, 1996 Koroshetz and Moskowitz, 1996 Ratan et al., 1994). Clinical trials of NMDA antagonists for stroke and traumatic brain injury have been abandoned (Kemp and McKeman, 2002 Lees et al., 2000 Sacco et al., 2001). 

Slanina, Z., Rudzinski, J. M. Osawa, E. 1987a C60 (g), C70 (g) saturated carbon vapour and increase of cluster populations with temperature a combined AMI quantum chemical and statistical-mechanics study. Coll. Czech. Chem. Commun. 52, 2831-2838. 

Shibasaki T, Koyama A, Hishida A, Muso E, Osawa G, Yamabe H, Shiiki H, Makino H, Sato H, Ishikawa I, Maeda K, Tomita K, Arakawa M, Ishida M, Sato M, Nagase M, Kashihara N, Yorioka N, Koike T, Saito T, Harada T, Mitarai T, Sugisaki T, Nagasawa T, Tomino Y, Nojima Y, Kobayashi Y, Sakai O. A randomized open-label comparative study of conventional therapy versus mizoribine onlay therapy in patients with steroid-resistant nephrotic syndrome (postmarketing survey). Clin Exp Nephrol 2004 8(2) 117-26. 

Kitamura K, Aihara M, Osawa J, Naito S, Ikezawa Z. Sulfhydryl drug-induced eruption a clinical and histological study. J Dermatol 1990 17(1) 44-51. 

Sunakawa K, Nonoyama M, Fuji R, Iwai N, Sakata H, Shirai M, Sato T, Kajino M, Toyonaga Y, Sano T, Naito A, Minagawa K, Niida Y, Oda T, Yokozawa M, Asanuma H, Shimura K, Fujimura M, Kitajima H, Fujinami K, Numazaki K, Fujikawa T, Kobayashi Y, Sato Y, Nishimura T, Iwata S, Tsuchihashi N, Oishi T, Matsumoto S, Motohiro T, Osawa M, Sunahara M, Shirakawa S, Nishida H, Takahashi N, Nakano R, Sai N, lyoda K, Yoshimitsu K, Ogawa K, Okazaki T, Tsukimoto I, Motoyama O, Takada Y, Kawasaki M, Sunaoshi W, Nakamura S, Ueda Y, Kamata M, Kato T, Chiba M, Ouchi K, Sato S, Horiuchi T, Suzuki K, Shimoyama T, Masaki H, Aikyo M, Kawada M, Banba M, Furukawa S, Okada T, Yamaguchi S, Hirota O, Koizumi S, Wada H, Ohta K, Uehara T, Yukitake K, Mori T, Takakuwa S, Matsuyama K. [Pharmacokinetic and clinical studies on teicoplanin for sepsis by methicillin-cephem resistant Staphylococcus aureus in the pediatric and neonate field.] Jpn J Antibiot 2002 55(5) 656-77. 

Osawa K, Kobayashi E, Okubo Y, Suwazono Y, KidoT, Nogawa K. A retrospective study on the relation between renal dysfunction and cadmium concentration in rice in individual hamlets in the Jinzu River basin, Toyama Prefecture, Japan. Environ Res 2001 86 51-59. 

J. and Osawa, Y. (1993) Studies on the mechanism of aromatase and other cytochrome P450 mediated deformylation reactions. The Journal of Steroid Biochemistry and Molecular Biology, 44 (4-6), 367-373. 

Figure 7). Osawa s recent force-field calculation study (21) of cage-shaped molecules with ethano bridges affords an excellent demonstration of this twist deformation at the molecular level. In six achiral cage-shaped molecules so far studied, his calculations showed that each molecule assumed a twisted, chiral conformation to minimize torsional and nonbonding strain. Tricyclo[4.2.2.2.2,s]dodecane (5) was shown to be 1.1 kcal/mol more stable in a twisted D2 than in the eclipsed D2h conformation, and his calculation also suggests that perhydrotriquinacene and C16-hexaquinane should assume C3 rather than conformations, contrary to naive pictures obtained by a casual observation of molecular models. 

Notably, in a study on mouse hepatocytes in vitro, D.A. Brenner and Y.Hannun confirmed that activation of ASMase and generation of eeramide (specifically of chain length Cl6) contributes to TNF-a-induced hepatocyte apoptosis (Osawa et al., 2005), but they did not see an involvement of downstream GD3 formation in their model. Another observation to be mentioned in this context is that TNF-a-induced apoptosis in the human myelogenous leukemia cells was blocked by the ASMase inhibitor SR33557 (Higuchi et al.,... 

Dekio, S., Takata, R., Osawa, S., Tanaka, K., and Tamaki, M. (1970). Genetic studies of the ribosomal proteins in Escherichia coli. IV. Pattern of the alteration of ribosomal protein components in mutants resistant to spectinomycin or erythromycin in different strains of Escherichia coli. Mol Gen. Genet. 107, 39 9. 

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