Oncogenesis

Besides the cytokine receptors that lack intrinsic kinase activity but have associated JAK kinases, STAT proteins can be activated by a variety of G-protein coupled receptors and growth factor receptors with intrinsic tyrosine kinase activity (for example EGF, PDGF, CSF-1, and angiotensin receptor). Increasing evidence suggests a critical role for STAT family members in oncogenesis and aberrant cell proliferation. Constitutively activated STATs have been found in many transformed cell lines and a wide variety of human tumor entities. Numerous non-receptor tyrosine kinases and viral oncoproteins, such as v-Src, v-Abl, v-Sis, and v-Eyk, have been identified to induce DNA-binding activity of STAT proteins. 

Oncogenesis is the process of cancer initiation the term is essentially synonymous with carcinogenesis. 

Family of transcription factors that modulate the expression of genes which control immune, inflammatory, and acute-phase responses, as well as cell growth, responses to stress, apoptosis, and oncogenesis. All members of this family have a Rel-homology domain that contains sequences responsible for dimerization and DNA binding. In vertebrates, this family includes NF-kB1 (also known as p50), NF-kB2 (also known as p52), Rel (also known as cRel), Rel-A (also known as p65), and Rel-B. 

Dasgupta P, Padmanabhan J, CheUappan S (2006) Rb function in the apoptosis and senescence of non-neuronal and neuronal cells role in oncogenesis. Curr Mol Med 6 719-729... 

The importance of pathways and networks was revealed by the study of the mechanisms of action of hormones, as well as by numerous studies on the mechanisms of oncogenesis and development. Biology articles and books... 

Neckers, L., Whitesel, L., Rosolen, A., and Geselowitz, D.A., Antisense inhibition of oncogene expression, Critical Reviews in Oncogenesis, 1992, 3, 175-231. 

Renauld, J.C., Kermouni, A., Vink, A., Louahed, J., and Van Snick, J. 1995. Interleukin-9 and its receptor involvement in mast cell differentiation and T-cell oncogenesis. Journal of Leukocyte Biology 57, 353-359. 

Ch. 25). This means that mutations in these proteins that result in alterations in their regulatory properties can lead to oncogenesis. Ras in particular has been implicated in several human cancers [32]. It has been estimated that as many as 30% of all human cancers contain mutations in one of the three Ras genes. While the frequency of Ras mutations in some types of human cancer is very low, its frequency in certain cancers, such as squamous cell carcinoma, lymphatic cancers and colorectal adenocarcinoma, is very high. 

B8. Bishop, J. M., Molecular themes in oncogenesis. Cell (Cambridge, Mass.) 64, 235-248 (1991). 

Several lines of experimental evidence provide prima facie evidence for a role of caveolin in oncogenesis. Consistent with a role in cancer, the caveolin-1 gene is localized to a putative tumor suppressor locus on chromosome 7 (7q31.11 D7S522) that is known to be missing in some types of cancers [42,... 

Bashir, T. and Pagano, M. Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis. Adv Cancer Res 2003, 88, 101-44. 

Several links have emerged between remodelling factors and oncogenesis (reviewed in Cairns, 2001). Subunits of the mammalian SWI/SNF complex possess intrinsic tumour suppressor function or are required for the activity of other... 

DNA lesions is critical for cell survival, and errors in this process can lead not only to cellular death but to oncogenesis. 

---