Oncogenes in humans

Pulciani S, Santos E, Lauver AV, et al. 1982b. Oncogenes in human tumor cell lines. Molecular cloning of a transforming gene from human bladder carcinoma cells. Proc Natl Acad Sci USA 79 2845-2849. [Pg.286]

Little CD, Nau MM, Carney DN et al. Amplifieation and expression of the c-Myc oncogene in human lung cancer eell lines. Nature 1983 306 194-196. [Pg.85]

Jiang W, Kahn SM, Guillem JG, Lu SH, Weinstein IB (1989) Rapid detection of ras oncogenes in human tumors applications to colon, esophageal, and gastric cancer. Oncogene 4 923-928... [Pg.830]

Ras genes are frequently mutated in chemically induced animal tumors and are the most frequently detected mutated oncogenes in human tumors. Approximately 20-30% of all human tumors contain mutated ras. The Ras subfamily includes H-ras, K-ras, and N-ra.v, and all have been found to be mutationally activated in numerous types of tumors from a large variety of species including humans. [Pg.246]

Lemoine, N. R., Staddon, S., Dickson, C., Barnes, D. M., and Gullick, W. J. (1990). Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer. Oncogene 5, 237-239. [Pg.416]

HER2/neu proto-oncogene in human breast and ovarian cancer. Science 244,... [Pg.417]

Kirsten-ras is the most frequently activated oncogene in human tumors (1). Activated K-ras is bound to GTP and possesses intrinsic GTPase activity which leads to its inactivation. Oncogenic K-ras has dramatically lower... [Pg.837]

Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, et al. 1989. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244 707-12... [Pg.223]

Alberti L, Carniti C, Miranda C, et al. RET and NTRKl proto-oncogenes in human diseases. J Cell Physiol 2003 195 168-86. [Pg.786]

The frequency of active ras oncogenes in human bladder cancer (F6) associated with schistosomiasis was examined. Of nine squamous cell carcinomas of the bladder, none scored as positive in the regular DNA transfection assay. The restriction fragment polymorphism assay at codon 12 of the H-ras gene confirmed the absence of an activating mutation at this site in all samples. Western blotting analyses of the ras p21 proteins suggested a point mutation with codon 61 in one sample only. Enhanced expression of the ras p21 protein was demonstrated in four samples. [Pg.223]

Yamanaka Y, Eriess H, Kobrin MS, et al. Overexpression of HER2/neu oncogene in human pancreatic carcinoma. Hum Pathol. 1993 24 1127-1134. [Pg.578]

See also Viral and cellular oncogenes, oncogenes and cell signalling. Oncogenes, Oncogenes in Human Tumors... [Pg.1400]

See also Eukaryotic DNA and Development, Oncogenes in Human Tumors (from Chapter 23), p53... [Pg.1406]

See also Oncogenes in Human Tumors, Oncogenes and Cell Signalling... [Pg.1418]

Spritz, R.A. Giebel, L.B. Holmes, S.A. Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism. Am. J. Hum. Genet., 50, 261-269 (1992)... [Pg.586]

Mollinedo F, Vaquerizo MJ, Naranjo JR Expression of c-jun,junB and junD proto-oncogenes in human peripheral-blood granulocytes. Biochem J 1991 273 477 79. [Pg.23]

Kroll, T.G., Sarraf, P., Pecciarini, L. et al. (2000) PAX8-PPARyl fusion oncogene in human thyroid carcinoma. Science, 289, 25. [Pg.270]

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