Oligosaccharide , synthesis

This concept can indeed be transferred to oligosaccharide syntheses using thioglycoside donors, as shown in Scheme 9.9192... 

A number of challenges still remain before a flexible, high-yielding, and absolutely selective strategy for the synthesis of oligosaccharides on the solid support becomes available. Once these problems are solved, the construction of an automated oligosaccharide synthesizer will become feasible. 

Figure 3.1 Oligosaccharides synthesized using the sulfoxide glycosylation method.

OLIGOSACCHARIDE SYNTHESES ON PEPTIDES ATTACHED TO A SOLID SUPPORT... 

Oligosaccharide syntheses employing enzymatic reactions would in principle greatly benefit from being performed on a polymer support since the support might effectively facilitate isolation of the final product. Presumably, a water-soluble polymeric support will be preferable to any insoluble support since reaction rates could otherwise become too slow. Glycosidases as synthetic enzymes would be the best candidates to study this type of the enzymic approach to oligosaccharide synthesis. 

Scheme 5.6 Poly-LacNAc-derived oligosaccharides synthesized by combinatorial biocatalysis [80].

R. R. Schmidt, New methods of glycoside and oligosaccharide syntheses—are there alternatives to the Koenigs-KnotT method, Angew. Chem. Int. Ed. Engl. 25 212 (1986). 

The experimental procedures for the selected sialyl-oligosaccharide syntheses are described in the following section. 

Fig. 4. Schematic design of an automated solid-phase oligosaccharide synthesizer.

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