Nuclear transporters

Stevenson M. Portals of entry uncovering HIV nuclear transport pathways. Trends Cell Biol 1996 6(1) 9-15. 

Pines, J., and Hunter, T. (1991a). Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J. Cell Biol. 115 1-17. 

Branden LJ, Mohamed AJ, Smith Cl (1999) A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA. Nat Biotechnol 17 784-787... 

Tomita, S., et. al., T cell-specific disruption of the aryl hydrocarbon receptor nuclear transporter (Amt) gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution, J. Immunol., 171, 4113, 2003. 

Aitchison, D, Blobel, G, Rout, MP. Kap 104p a karyopherin involved in the nuclear transport of messenger RNA-DNA binding proteins. Science 1996 274 ... 

The family of eukaryotic Ras-like small GTPases may be divided into subfamilies, namely those of ARF, Rab, Ran, Ras, Rho, and Sar (ARF, RAB, RHO, RAS, RHO, SAR), which all contain representatives from fungi, plants, and metazoa. Consequently, these subfamilies and their cellular functions are likely to have emerged early in eukaryotic history. This implies that the last common ancestor of fungi, plants, and metazoa possessed vesicular transport (ARF and Sar), membrane trafficking (Rab), nuclear transport (Ran), signal transduction (Ras), and regulation of the actin cytoskeleton (Rho) functions. 

Sumo (Smt3, Sentrin) Many Nuclear transport, localization, regulation... 

Jans DA, Xiao CY, Lam MH. Nuclear targeting signal recognition a key control point in nuclear transport Bioessays 2000 22(6) 532-544. 

Eritja R, Pons A, Escarceller M, et al. Synthesis of defined peptide-oligonucleotide hybrids containing a nuclear transport signal sequence. Tetrahedron 1991 47 4113-4120. 

Hochstrasser M (1998) There s the rub a novel ubiquitin-like modification linked to cell cycle regulation. Genes Dev 12 901-907 Hochstrasser M, Johnson PR, Arendt CS, Amerik AY, Swaminathan S, Swanson R, Li SJ, Laney J, P s Ryiaarsdam R, Now J, Connerly PL (1999) The Saccharomyces cerevisiae ubiquitin-proteasome system. Philosophical Transactions of the Royal Society of London Series B Biological Sciences 354 1513-1522 Honda R, Tanaka, H Yasuda H (1997) Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 420 25-27 Hood JK, Silver PA (1999) In or out Regulating nuclear transport. Curr Opin Ceil Biol 11 241-247... 

The steroid hormone receptors are phophoproteins which are usually phosphorylated on several positions. The phosphorylation sites are mainly foimd in the N-terminal region of the receptors. Serine phosphorylation prevails. One rare example of tyrosine phosphorylation is described for the case of estrogen receptors. The consequences of phosphorylation for the receptor proteins are varied. It is conceivable, and in some cases experimentally proven, that it has influence on hormone binding, nuclear transport, DNA binding and transactivation. 

Guinez, C., Morelle, W., Michalski, J. C., and Lefebvre, T. (2005). O-GlcNAc glycosylation A signal for the nuclear transport of cytosolic proteins Int. ]. Biochem. Cell Biol. 37, 765-774. 

Collas, P. and Alestrom, P. (1997a) Nuclear localization signals a driving force for nuclear transport of plasmid DNA in zebrafish. Biochem. Cell Biol., 75, 633-640. 

Vodicka, M.A., Koepp, D.M., Silver, P.A. and Emerman, M. (1998) HIV-l Vpr interacts with the nuclear transport pathway to promote macrophage infection. Genes Dev., 12,175-185. 

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