Membrane trafficking

Annexins form an evolutionary conserved family of Ca2+ and phospholipid binding proteins implicated in membrane trafficking and the regulation of Ca2+ currents across membranes. 

Researchers found that NAD serves as a substrate in poly(ADP-ribose) synthesis, a reaction important for DNA repair processes. In addition, it takes part in mono (ADP-ribosyl)ation reactions that are involved in endogenous regulation of many aspects of signal transduction and membrane trafficking in eukaryotic cells. 

Siripurapu V, Meth J, Kobayashi N, Hamaguchi M. DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways. / Mol Biol 2005 346 83-9. 

Beaumont, V. (2003). Visualizing membrane trafficking using total internal reflection fluorescence microscopy. Biochem. Soc. Trans. 31, 819-23. 

GENERAL MECHANISMS OF INTRACELLULAR MEMBRANE TRAFFICKING IN MAMMALIAN CELLS INCLUDE BOTH UNIVERSAL AND HIGHLY SPECIALIZED PROCESSES 139... 

FUNDAMENTALS OF MEMBRANE TRAFFICKING ARE BASED ON A SET OF COMMON PRINCIPLES 141... 

In this chapter, the basic mechanisms of membrane trafficking and the functions of the biosynthetic, secretory... 

G proteins have been implicated in membrane trafficking 338... 

A third type of bacterial toxin, diphtheria toxin, catalyzes the ADP-ribosylation of eukaryotic elongation factor (EFTU), a type of small G protein involved in protein synthesis (Table 19-2). The functional activity of the elongation factor is inhibitedby this reaction. Finally, a botulinum toxin ADP-ribosylates and disrupts the function of the small G protein Rho, which appears to be involved in assembly and rearrangement of the actin cytoskeleton (Table 19-2). These toxins maybe involved in neuropathy (see Ch. 36) and membrane trafficking (see Ch. 9). 

The family of eukaryotic Ras-like small GTPases may be divided into subfamilies, namely those of ARF, Rab, Ran, Ras, Rho, and Sar (ARF, RAB, RHO, RAS, RHO, SAR), which all contain representatives from fungi, plants, and metazoa. Consequently, these subfamilies and their cellular functions are likely to have emerged early in eukaryotic history. This implies that the last common ancestor of fungi, plants, and metazoa possessed vesicular transport (ARF and Sar), membrane trafficking (Rab), nuclear transport (Ran), signal transduction (Ras), and regulation of the actin cytoskeleton (Rho) functions. 

DUBs are clearly an essential cellular component needed for a variety of pathways including protein degradation, DNA repair, apoptosis, membrane trafficking, stress... 

S Additional information <4, 8> (<8> the class II phosphoinositide 3-ki-nase C2a is activated by clathrin and regulates clathrin-mediated membrane trafficking [9] <4> TNFa and leptin stimulate the a-isoform of class II phosphoinositide 3-kinase [5] <8> PI3K-C2cr and PI3K-C2/1 represent two downstream targets of the activated epidermal growth factor... 

Discussion of the roles of phosphatidylinositol derivatives in signal transduction, cytoskeletal regulation, and membrane trafficking. 

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