Nuclear analytical techniques metallome/metalloproteome

Nuclear Analytical Techniques for Metallome and Metalloproteome Distribution... 

Nuclear Analytical Techniques for the Structural Analysis of Metallomes and Metalloproteomes... 

This book is written by experts from disciplines as diverse as analytical chemistry, nuclear chemistry, environmental science, molecular biology, and medicinal chemistry in order to identify potential hot spots of metallomics and metalloproteomics. The scientific fundamentals of new approaches, like isotopic techniques combined with ICP-MS/ESI-MS/MS, the synchrotron radiation-based techniques. X-ray absorption spectroscopy, X-ray diffraction, and neutron scattering, as well as their various applications, with a focus on mercury, selenium, chromium, arsenic, iron and metal-based medicines are critically reviewed, which can help to understand their impacts on human health. The book will be of particular interest to researchers in the fields of environmental and industrial chemistry, biochemistry, nutrition, toxicology, and medicine. Basically, the book has two aims. The first deals with the educational point of view. Chapters 2 to 7 provide the basic concept of each of the selected nuclear analytical techniques and should be understandable by Master and PhD students in chemistry, physics, biology and nanotechnology. The... 

The progress in metallomics and metalloproteomics is critically dependent on advances in methods for in silico (bioinformatics), in vitro and in vivo analysis bringing information on the identity, concentration, and localisation of elements and their species. Nuclear analytical techniques are a basic instrumental toolbox enabling and facilitating the acquisition of the relevant analytical information. They include, in the broader sense, not only neutron activation. 

As a key lab of Chinese Academy of Sciences, most of the important nuclear analytical techniques are available and also open to external users from various disciplines. In addition, the synchrotron radiation facility in our institute provides useful beamlines for metallomics and metalloproteomics-related researches. Therefore, based on these convenient conditions, we have developed related methodology and application over the past 20 years. In this book, we outline our main achievements and current progress in the metallomics and metalloproteomics on several important elements (Hg, Se, As, REEs, etc) and nanomaterials made within the last 10 years. 

Yuxi Gao is an associate professor at Institute of High Energy Physics, Chinese Academy of Sciences. He obtained his PhD degree in environmental sciences in 2000 from Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. His current research focuses on the methodology of metallomics and metallo-proteomics based on the nuclear analytical techniques the applications of metallomics and metalloproteomics tourniquets on the environmental and biomedical research the homeostasis of trace elements and their regulatory mechanism the structure, function and structure-function relationship of important metalloproteins. 

The intent of this book is to provide readers with a comprehensive view of application of advanced nuclear and relevant analytical techniques for a new scientific frontier metallomics and metalloproteomics , which are becoming the hot topics in bioanalytical chemistry and life sciences. 

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