Nuclear acids

Furthermore, it was found that stimulated human neutrophils are able to produce 5-chloro-2 -deoxycytidine and that the myeloperoxidase system generates just the same levels of 5-chlorocytosine in DNA and RNA in vitro (Reaction (4), Figure 28.3). It is possible that myeloperoxidase-generated chlorinated products may modify nuclear acids of pathogens and nuclear acids in host cells during inflammation. Hawkins et al. [48] suggested that DNA oxidation may be initiated by protein chloramines formed in the reaction of HOCl with histones in the nucleosome. 

Munakata T, Adachi N, Yokoyama N, Kuzuhara T, Horikoshi M (2000) A human homolog of yeast anti-silencing factor has histone chaperone activity. Genes to Cells 5 221-233 Okuwaki M, Matsumoto K, Tsujimoto M, Nagata K (2001) Function of nucleophosmin/B23, a nuclear acidic protein, as a histone chaperone. FEBS Lett 506 272-276 Owen-Hughes T (2003) Colworth memorial lecture. Pathways for remodeling chromatin. Biochem. Soc.Trans 31 893-905... 

Thus polydentate organophosphorus compounds appear to be efficient extractants of trivalent TPE from acidic solutions. The full-scale use of these compounds in, for instance, TPE extraction from nuclear acidic waste solutions seems very likely in the future. 

T. Uragami, M. Yamamoto and K. Moriyama, Transport of nuclear acid bases through cation exchange membranes from poly(styrenesulfonic acid) and poly(vinyl alcohol), J. Membr. Sci., 1991, 61, 227-237. 

An Assay for Targeted Nuclear Acid Repair for Gene Therapy in Yeast... 

Nucleic acid nu- kle-ik- [fr. their occurrence in cell nuclei] (1892) n. A family of macromolecules, of molecular masses ranging upward from 25,000, found in the chromosomes, nucleoli, mitochondria, and cytoplasm of all cells, and in viruses in complexes with proteins, they are called nu-cleoproteins. On hydrolysis they yield purines, pyrimidines, phosphoric acid, and a pentose, either D-ribose or D-deoxyribose from the last, the nucleic acid derive their more specific names, ribronucleic acid and deoxyribonucleic acid. Nuclear acids are liner (i.e., unbranched) chains of nucleotides in which the 5 -phosphoric group of each one is esterified with the 3 -hydroxyl of the adjoining nucleotide. Black JG (2002) Microbiology, 5th edn. John Wiley and Sons Inc., New York. 

The dynamics of macromolecules on the atomic level is one of the most prominent applications of particle methods. With such methods it is possible to simulate molecular fluids, crystals, amorphous polymers, liquid crystals, zeolites, nuclear acids, proteins, membranes and many more biochemical materials [50]. 

The nucleus is surrounded by a nuclear membrane and contains chromatin, which is composed of deoxyribonucleic acid (DNA), wherein reside the genes, histones (basic protein), nuclear acidic protein, and one or more nucleoli which contain ribonucleic acid (RNA). The histones and DNA are organized into nucleosomes (see Chapter 7). It has been estimated that each nucleus contains 6.2 pg of DNA (Vendrely and Vendrely, 1956). The mitochondria have an inner and outer membrane and contain the pyruvate dehydrogenase multi enzyme... 

Johnson, E. M., and Hadden, J. W., 1975, Phosphorylation of lymphocyte nuclear acidic proteins regulation by cyclic nucleotides. Science 187 1198. 

Tsuboi, A., and Baserga, R., 1972, Synthesis of nuclear acidic proteins in density-inhibited fibroblasts stimulated to proliferate, /. Cell Physiol. 80 107. 

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